Micronucleus In Exfoliated Buccal Cells Of Crack Users: Systematic Review And Meta-Analysis

Creators:Tavella, Ronan Adler, dos Santos, Marina; Universidade Federal do Rio Grande, da Silveira, Tatiane Brito; Universidade Federal do Rio Grande, Fernandes, Caroline Lopes Feijo; Universidade Federal do Rio Grande, Da Silva Júnior, Flavio Manoel Rodrigues; Universidade Federal do Rio Grande
2021-06-24

Colaborador:

  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Materia:

Descripción

This research aimed to conduct a systematic review and metanalysis to compare the frequency of cell damage in crack users and non-crack users, through Micronucleous (MN) test in buccal mucosa cells. A comprehensive search was carried out on MEDLINE via PubMeb, Web of Science, LILACS and the grey literature without restrictions. It was included case-control studies that report the frequency of micronuclei in the oral mucosa of adult crack users and non-crack users. A review protocol were registered with PROSPERO (CRD42018115672), and conducted in accordance with the PRISMA guidelines for the report of this systematic review. Furthermore, study quality was evaluated using an adapted Newcastle-Ottawa Scale for cross-sectional studies. The original search yielded 27 references, after eligibility criteria a total of five articles were included. The number of micronuclei was higher in crack users compared to non-crack users. Also, secondary outcomes: binucleated cells, nuclear buds, pyknosis, karyorrhexis and karyolysis had higher prevalence in crack users. Crack use is associated with genotoxic and mutagenic effects because there is a higher frequency of micronuclei in exfoliated cells of crack users. In addition, MN test proved to be an established biomarker to assess the mutagenic impact of crack use in oral epithelium.

Metadatos destacados

Colecciones
Alternativa. Revista de Estudios Rurales

Editor

Asociación Toxicológica Argentina

Fuente

Acta Toxicológica Argentina; Vol 28, No 2 (2020); 36-44

Citación

Tavella, Ronan Adler et al., “Micronucleus In Exfoliated Buccal Cells Of Crack Users: Systematic Review And Meta-Analysis,” Archivo PPCT, consulta 1 de abril de 2026, http://archivoppct.caicyt.gov.ar/items/show/2650.

Dublin Core

Materia

Autor

Tavella, Ronan Adler
dos Santos, Marina; Universidade Federal do Rio Grande
da Silveira, Tatiane Brito; Universidade Federal do Rio Grande
Fernandes, Caroline Lopes Feijo; Universidade Federal do Rio Grande
Da Silva Júnior, Flavio Manoel Rodrigues; Universidade Federal do Rio Grande

Fuente

Acta Toxicológica Argentina; Vol 28, No 2 (2020); 36-44

Editor

Asociación Toxicológica Argentina

Fecha

2021-06-24

Colaborador

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Derechos

Acta Toxicológica Argentina es una publicación de acceso abierto yposee una Licencia Pública de Creative Commons (CC-BY-NC). Los autores conservan los derechos de autor y garantizan a la revista el derecho de ser la primera publicación del trabajo. Los autores retienen el derecho sobre sus trabajos bajo las normas de la licencia CC de tipo BY-NC, Licencia Pública de Creative Commons que permite compartir el trabajo reconociendo su publicación inicial en esta revista, pudiendo los autores disponer del trabajo para el fin que consideren, con la sola exepción de su reproducción con fines comerciales, de acuerdo a este tipo de licencia de CC.
Acta Toxicológica Argentina is an open access journal and has a Creative Commons Public License (CC-BY-NC). Authors retain copyright on their work, nevertheless they guarantee the journal the right to be the first in its publication. Authors retain the rights of their work under the guidelines of the license CC BY-NC, Creative Commons Public License. They can freely share their work (always recognizing its initial publication in this journal) with the sole exception of its reproduction for commercial purposes, according to this kind of CC license.
Acta Toxicológica Argentina é uma open access publicaçao comuma Licença Pública Creative Commons (CC-BY-NC). Autores mantém seus direitos autorais e garantir a o revista o direito de ser a primeira em publicação da obra. Autores mantém os direitos a seu trabalho sob as regras da licença CC BY-NC, Licença Pública Creative Commons para a partilha de trabalho, reconhecendo sua publicação inicial nesta revista. Os autores são livres para usar a obra para qualquer fim, menos comercial, de acordo com este tipo de licença CC.

Formato

Idioma

spa

Tipo

info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion