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L6CN yTHBN,yF[^$+>EBA# DūW0Q(?+U>?6MO3K/IVjs^rވj tu^t{WuWt+]]u+mpzW^oW ~w`̃/5o` F8NAG7׮]m7{j*Г U½zO^zAxB%jqX/։[ZF UbX!O􊜈w[<.L#B/ X76S&B"uN`5J촹7 t 1?`9oJǮtv7oDP klv,dHdsCC9iį Wsrhټ5~;.4y J`]l3iw3CYppg1H2Lv%L6=9 űl+t;`08;gk]NZc;W7 [`z+ʊ endstream endobj 1004 0 obj <>/Font<>>>/Fields[]>> endobj 1005 0 obj <> endobj 1017 0 obj <>/Filter/FlateDecode/ID[]/Info 83 0 R/Length 540/Root 980 0 R/Size 1018/Type/XRef/W[1 3 1]>>stream h옿kTAgg=M%,Q\PXH XX1 "F A#NlBQ4ƻݽu1O"W(|>;;;Xx0Ld3bG]WHaeݴ*IeCcM`ĆfT8I<%t3Սm?l8XAqT8 3u[[ L XVEe}˒FS̩mS9GGv\Pvɢae|k鹝!+5 Qߗ]#nz{\:/fg}ǽ\PyG"-.eEJytn[HoǝS?ITmbǜ/?s ӰB5U Perfiles de síntesis y secreción de los péptidos natriuréticos durante la evolución de la hipertrofia cardíaca en ratas hipertensas DOCA-sal - Archivo PPCT

Perfiles de síntesis y secreción de los péptidos natriuréticos durante la evolución de la hipertrofia cardíaca en ratas hipertensas DOCA-sal;
Natriuretic Peptides Synthesis and Secretion Profiles during the Evolution of Cardiac Hypertrophy in DOCA-Salt Hypertensive Rats

Creators:Cerrudo, Carolina; Cátedra de Fisiopatología, INFIBIOC (Instituto de Fisiopatología y Bioquímica Clínica), Facultad de Farmacia y Bioquímica, Universidad de Buenos
Aires, CONICET, Rodriguez Fermepin, Martin, Cavallero, Susana, Saucedo, Silvia, Hertig, Cecilia, Fernandez, Belisario
2012-01-04

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Descripción

RESUMENDurante el desarrollo de la hipertensión arterial, las interacciones entre las sobrecargas de presión y de volumen conducen a diferentes patrones de hipertrofia cardíaca y a un aumento de los péptidos natriuréticos (PN). Los perfiles de síntesis y secreción de ANP y BNP se han investigado en modelos de hipertensión arterial; sin embargo, aún no se ha estudiado la evolución diferencial de estos perfiles durante períodos agudos y crónicos de la hipertrofia cardíaca producida por sobrecarga de volumen. Por este motivo estudiamos ratas Sprague-Dawley con el modelo DOCA-sal a las 2, 4, 6 y 12 semanas, correlacionando la evolución de dichos perfiles con la hipertrofia cardíaca y la hipertensión arterial.

The interactions between pressure and volume overload that occur in hypertension lead to different patterns of cardiac hypertrophy and to increase in natriuretic peptides (NPs). The profiles of ANP and BNP synthesis and secretion have been investigated in models of hypertension; however, the different evolution of these profiles during the acute and chronic periods of pressure overload-induced cardiac hypertrophy is still unknown. For this reason, we studied DOCA-salt treated Sprague-Dawley rats at weeks 2, 4, 6 and 12 and correlated the evolution of these profiles with cardiac hypertrophy and hypertension. Cardiac hypertrophy had a positive correlation with ANP expression in the left ventricle and with ANP plasma levels. BNP expression increased after 4 weeks of treatment while ANP increased significantly after 6 weeks. In addition, BNP plasma levels increased only in the group treated for 12 weeks, while ANP plasma levels increased from week 2. NP secretion has a differential response in the early stages of the development of cardiac hypertrophy induced by the DOCA-salt model, with an early increase in ANP. As ANP levels were exceeded to those of BNP in all the DOCA-salt groups, ANP might be considered a more specific marker of volume overload.

Metadatos destacados

Colecciones
Argentine Journal of Cardiology

Editor

Sociedad Argentina de Cardiología

Fuente

Revista Argentina de Cardiología; Vol 79, No 6 (2011); 493-499, Argentine Journal of Cardiology; Vol 79, No 6 (2011); 493-499

Citación

Cerrudo, Carolina; Cátedra de Fisiopatología, INFIBIOC (Instituto de Fisiopatología y Bioquímica Clínica), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, CONICET et al., “Perfiles de síntesis y secreción de los péptidos natriuréticos durante la evolución de la hipertrofia cardíaca en ratas hipertensas DOCA-sal,” Archivo PPCT, consulta 2 de abril de 2026, http://archivoppct.caicyt.gov.ar/items/show/7983.

Dublin Core

Materia

Autor

Cerrudo, Carolina; Cátedra de Fisiopatología, INFIBIOC (Instituto de Fisiopatología y Bioquímica Clínica), Facultad de Farmacia y Bioquímica, Universidad de Buenos
Aires, CONICET
Rodriguez Fermepin, Martin
Cavallero, Susana
Saucedo, Silvia
Hertig, Cecilia
Fernandez, Belisario

Fuente

Revista Argentina de Cardiología; Vol 79, No 6 (2011); 493-499
Argentine Journal of Cardiology; Vol 79, No 6 (2011); 493-499

Editor

Sociedad Argentina de Cardiología

Fecha

2012-01-04

Derechos

Los que firman al pié, certificamos que tenemos total responsabilidad por la conducción de este estudio y por el diseño y la interpretación de los datos. Nosotros escribimos el manuscrito y somos responsables por la decisión acerca del mismo. Cada uno de nosotros cumple la definición de autor como se afirma en el Comité Internacional de Editores de Revistas Médicas (International Committee of Medical Journal Editors, ver www.icmje.org). Nosotros hemos visto y aprobado el manuscrito final. Ni el artículo, ni ninguna parte esencial del mismo, incluido las tablas y las figuras, será publicado o admitido para arbitrar a otra parte antes de aparecer en la Revista.También notificamos haber leído la sección “conflicto de intereses”, y revelaríamos cualquiera que existiera. Dejamos constancia que si nuestro artículo se publicara en la RAC, cederíamos los derechos (copyright) a la Revista.Los documentos publicados en esta revista están bajo la licencia Creative Commons Atribución-NoComercial-Compartir-Igual 2.5 Argentina.
Those signing below certify that we have full responsibility for the conduction of this study and for the design and interpretation of the information. We wrote the manuscript and are responsible for its decision. Each of us fulfills the definition of authorship as stated by the International Committee of Medical Journal Editors ( www.icmje.org). We have signed and approved the final manuscript. Neither the manuscript, nor any essential part thereof, including tables and figures, will be published or accepted for refereeing elsewhere before being published in the Journal. We have also read the "Conflict of Interest" section and would disclose any existing. We state that if our manuscript is published in the RAC, we shall transfer the copyright to the Journal.

Formato

Idioma

spa
eng

Tipo

info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion