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0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f trailer <<68873708A2C5B44F904A9108DFE52A1E>]>> startxref 116 %%EOF Asociación de valores de proteína C reactiva preoperatoria con complicaciones en el posoperatorio de cirugía cardiovascular - Archivo PPCT

Asociación de valores de proteína C reactiva preoperatoria con complicaciones en el posoperatorio de cirugía cardiovascular;
Association between Preoperative C-Reactive Protein Levels with Postoperative Complications of Cardiovascular Surgery

Creators:Waldman, Silvina; FLENI - Departamento de Cardiología, Poggio, Rosana, Carrizo, Laura, Rodriguez, Walter, Sellanes, Miguel, Grancelli, Hugo, Pensa, Claudio, Carnevalini, Mariana, Cohen Arazi, Hernan
2011-12-16

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RESUMENIntroducciónEl síndrome de respuesta inflamatoria sistémica es una complicación frecuente en el posoperatorio de cirugía cardíaca, que puede evolucionar con shock vasopléjico y los casos más graves pueden derivar en falla de uno o más órganos. Se describieron predictores en el preoperatorio y el perioperatorio asociados con esta complicación; sin embargo, un estado de inflamación subclínico en la etapa preoperatoria, no detectado por estudios de rutina, podría relacionarse con la respuesta inflamatoria desencadenada en el posoperatorio. Niveles elevados de proteína C reactiva (PCR), un parámetro de inflamación en diferentes escenarios clínicos y que se asocia con el pronóstico de diversas patologías cardiovasculares, podrían predecir el síndrome.ObjetivoEvaluar la contribución de la elevación de los niveles preoperatorios de proteína C reactiva para predecir el síndrome de respuesta inflamatoria sistémica y sus complicaciones posoperatorias en cirugía cardíaca.Material y métodosSe incluyeron 169 pacientes consecutivos, prospectivos (77,3% hombres, edad 61,1 ± 15,9, Euroscore 9,46 [DE 12,7]) sometidos a cirugía cardíaca entre abril de 2007 y diciembre de 2008. Se determinó el nivel de PCR en todos los pacientes. El punto final combinado incluyó síndrome de respuesta inflamatoria sistémica y su asociación con fibrilación auricular, insuficiencia renal, shock o muerte.

BackgroundSystemic inflammatory response syndrome is a frequent postoperative complication of cardiovascular surgery that can develop vasoplegic shock and organ or multiorgan dysfunction in the most severe cases. Preoperative and postoperative predictors associated with this complication have been described; however, a subclinical preoperative inflammatory state, not detected by routine tests, might be related to the postoperative inflammatory response. Elevated C-reactive protein (CRP) levels, a parameter of inflammation in different clinical scenarios that is associated with the prognosis of diverse cardiovascular diseases, might predict the syndrome.ObjectiveTo evaluate the value of elevated C-reactive protein to predict systemic inflammatory response syndrome and its postoperative complications after cardiovascular surgery.Material and MethodsA total of 169 consecutive patients (77.3% were men, age 61.1±15.9, Euroscore 9.46 [SD 12.7]) undergoing cardiovascular surgery were prospectively included between April 2007 and December 2008. CRP levels were determined in all patients. The combined endpoint included the incidence of systemic inflammatory response syndrome and its association with atrial fibrillation, kidney failure, shock or death.ResultsEighty seven patients (54%) developed systemic inflammatory response syndrome and 50 patients (31%) presented the combined endpoint. In-hospital mortality was 5.6% (9 patients).The preoperative levels of CRP ≥2 mg/dl adjusted for preoperative and postoperative variables were independently associated with the combined endpoint (OR 2.95, 95% CI 1.20-7.23; p&lt;0.018), with the development of systemic inflammatory response syndrome (SIRS) (OR 2.46, 95% CI 1.17-5.15; p&lt;0.000), and with the combination of SIRS and kidney failure (OR 5.10, 95% CI 1.48-17.58; p&lt;0.010), SIRS and shock (OR 6.50, 95% CI 1.59-27.34; p&lt;0.005), and SIRS kidney failure (OR 2.91, 95% CI 1.19-7.12; p&lt;0.019) and shock (OR 4.13, 95% CI 1.25-13.60; p &lt; 0.020).ConclusionsPreoperative levels of CRP ≥2.0 mg/dl may predict the systemic inflammatory response syndrome and the systemic inflammatory response syndrome with kidney failure, atrial fibrillation, shock and death in the postoperative period of cardiovascular surgery.

Metadatos destacados

Colecciones
Argentine Journal of Cardiology

Editor

Sociedad Argentina de Cardiología

Fuente

Revista Argentina de Cardiología; Vol 78, No 6 (2010); 492-498, Argentine Journal of Cardiology; Vol 78, No 6 (2010); 492-498

Citación

Waldman, Silvina; FLENI - Departamento de Cardiología et al., “Asociación de valores de proteína C reactiva preoperatoria con complicaciones en el posoperatorio de cirugía cardiovascular,” Archivo PPCT, consulta 2 de abril de 2026, http://archivoppct.caicyt.gov.ar/items/show/8012.

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Materia

Autor

Waldman, Silvina; FLENI - Departamento de Cardiología
Poggio, Rosana
Carrizo, Laura
Rodriguez, Walter
Sellanes, Miguel
Grancelli, Hugo
Pensa, Claudio
Carnevalini, Mariana
Cohen Arazi, Hernan

Fuente

Revista Argentina de Cardiología; Vol 78, No 6 (2010); 492-498
Argentine Journal of Cardiology; Vol 78, No 6 (2010); 492-498

Editor

Sociedad Argentina de Cardiología

Fecha

2011-12-16

Derechos

Los que firman al pié, certificamos que tenemos total responsabilidad por la conducción de este estudio y por el diseño y la interpretación de los datos. Nosotros escribimos el manuscrito y somos responsables por la decisión acerca del mismo. Cada uno de nosotros cumple la definición de autor como se afirma en el Comité Internacional de Editores de Revistas Médicas (International Committee of Medical Journal Editors, ver www.icmje.org). Nosotros hemos visto y aprobado el manuscrito final. Ni el artículo, ni ninguna parte esencial del mismo, incluido las tablas y las figuras, será publicado o admitido para arbitrar a otra parte antes de aparecer en la Revista.También notificamos haber leído la sección “conflicto de intereses”, y revelaríamos cualquiera que existiera. Dejamos constancia que si nuestro artículo se publicara en la RAC, cederíamos los derechos (copyright) a la Revista.Los documentos publicados en esta revista están bajo la licencia Creative Commons Atribución-NoComercial-Compartir-Igual 2.5 Argentina.
Those signing below certify that we have full responsibility for the conduction of this study and for the design and interpretation of the information. We wrote the manuscript and are responsible for its decision. Each of us fulfills the definition of authorship as stated by the International Committee of Medical Journal Editors ( www.icmje.org). We have signed and approved the final manuscript. Neither the manuscript, nor any essential part thereof, including tables and figures, will be published or accepted for refereeing elsewhere before being published in the Journal. We have also read the "Conflict of Interest" section and would disclose any existing. We state that if our manuscript is published in the RAC, we shall transfer the copyright to the Journal.

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spa
eng

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info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion