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65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f trailer <]>> startxref 116 %%EOF Papel antioxidante de la vitamina E en la aterogénesis inducida por hiperfibrinogenemia - Archivo PPCT

Papel antioxidante de la vitamina E en la aterogénesis inducida por hiperfibrinogenemia;
Antioxidant Role of Vitamin E in Atherogenesis Induced by Hyperfibrinogenemia

Creators:Llorens, Candelaria; Cátedra de Física Biomédica, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba
Becaria MYNCYT, Baez, Ma. del Carmen, Taran, Mariana, Campana, Vilma, Fonseca, Ismael, Oyola, Elsa, Palma, Jose, Moya, Monica
2011-12-20

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RESUMENCon el propósito de estudiar el efecto de la vitamina E sobre el estrés oxidativo desencade- nado por hiperfibrinogenemia (HF) en un modelo experimental de aterogénesis y la posible normalización de los indicadores de estrés oxidativo, se evaluaron: óxido nítrico (NO), L-citrulina, superóxido dismutasa (SOD) e involución de lesiones histopatológicas en la aorta torácica. El estudio se realizó en 36 ratas, cepa Wistar, que se dividieron en tres grupos (n = 12 cada uno): A, control; B, HF × 90 días; C, HF × 90 días + vitamina E. La HF se indujo mediante inyecciones de adrenalina (0,1 ml/día/rata) por 90 días. La dosis de vitamina E fue de 2 mg/día/rata durante 75 días. Se dosaron en plasma los niveles de fibrinógeno (mg/dl), NO (uM) y L-citrulina (mM) y en lisado de glóbulos rojos, por espectrofotometría, se determinó la actividad de la SOD (U/ml). Se analizaron cortes de la aorta torácica por microscopia óptica (MO). Rev Argent Cardiol 2010;78:405-410.

We used an experimental model of atherogenesis to evaluate the effect of vitamin E on oxidative stress induced by hyperfibrinogenemia (HF) and the possible normalization of oxidative stress markers. The following variables were studied: nitric oxide (NO), L-citrulline, superoxide dismutase (SOD) activity and regression of histopathological lesions in the thoracic aorta. The study was performed in 36 Wistar rats that were divided into three groups of 12 rats each: A, control group; B, HF for 90 days; C, HF for 90 days + vitamin E. Hyperfibrinogenemia was induced by the injection of epinephrine (0.1 ml/day/rat) during 90 days. The dose of vitamin E was 2 mg/day/rat during 75 days. We measured the plasma levels of fibrinogen (mg/dl), NO (uM) and L-citrulline (mM); SOD activity (U/ml) was assayed in red cell lysates using spectrophotometry. The histopathological sections of the thoracic aorta were examined using light microscopy (LM). Statistical analysis was performed using MANOVA and Fisher’s test; a p value &lt;0.05 was considered statistically significant. Rats in group B had a significant increase in fibrinogen levels B (407±8.9 mg/dl) compared to groups A (203±9 mg/dl) and C (191.58±17.79 mg/dl) (p&lt;0.001). We observed a significant decrease in NO in group B (13.73±1.76 uM) versus groups A (23.58±0.08 uM) and C (26.64±3.65 uM) (p&lt;0.001). L-citrulline increased significantly in groups B (4.99±0.18 mM) and C (6.60±0.16 mM) compared to group A (3.03±0.13 mM) (p&lt;0.001). SOD activity was greater in groups B (251.67±10.34 U/ml) and C (304.75±10.43 U/ml) versus group A (139.44±4.74 U/ml) (p&lt;0.001). Light microscopic examination revealed the presence of endothelial denudation, intimal thickening and vessel wall protrusion in group B (90%), while recovery of endothelial denudation and a 50% reduction in intimal thickening was observed in group C (p&lt;0.001). High SOD activity might be insufficient to prevent abnormalities in the oxidative stress pathway induced by HF. Vitamin E would stop the chain reaction initiated by free radicals and thus decrease the superoxide anion, stimulating the bioavailability of NO with normalization of fibrinogen plasma levels.

Metadatos destacados

Colecciones
Argentine Journal of Cardiology

Editor

Sociedad Argentina de Cardiología

Fuente

Revista Argentina de Cardiología; Vol 78, No 5 (2010); 405-410, Argentine Journal of Cardiology; Vol 78, No 5 (2010); 405-410

Citación

Llorens, Candelaria; Cátedra de Física Biomédica, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba Becaria MYNCYT et al., “Papel antioxidante de la vitamina E en la aterogénesis inducida por hiperfibrinogenemia,” Archivo PPCT, consulta 2 de abril de 2026, http://archivoppct.caicyt.gov.ar/items/show/8028.

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Autor

Llorens, Candelaria; Cátedra de Física Biomédica, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba
Becaria MYNCYT
Baez, Ma. del Carmen
Taran, Mariana
Campana, Vilma
Fonseca, Ismael
Oyola, Elsa
Palma, Jose
Moya, Monica

Fuente

Revista Argentina de Cardiología; Vol 78, No 5 (2010); 405-410
Argentine Journal of Cardiology; Vol 78, No 5 (2010); 405-410

Editor

Sociedad Argentina de Cardiología

Fecha

2011-12-20

Derechos

Los que firman al pié, certificamos que tenemos total responsabilidad por la conducción de este estudio y por el diseño y la interpretación de los datos. Nosotros escribimos el manuscrito y somos responsables por la decisión acerca del mismo. Cada uno de nosotros cumple la definición de autor como se afirma en el Comité Internacional de Editores de Revistas Médicas (International Committee of Medical Journal Editors, ver www.icmje.org). Nosotros hemos visto y aprobado el manuscrito final. Ni el artículo, ni ninguna parte esencial del mismo, incluido las tablas y las figuras, será publicado o admitido para arbitrar a otra parte antes de aparecer en la Revista.También notificamos haber leído la sección “conflicto de intereses”, y revelaríamos cualquiera que existiera. Dejamos constancia que si nuestro artículo se publicara en la RAC, cederíamos los derechos (copyright) a la Revista.Los documentos publicados en esta revista están bajo la licencia Creative Commons Atribución-NoComercial-Compartir-Igual 2.5 Argentina.
Those signing below certify that we have full responsibility for the conduction of this study and for the design and interpretation of the information. We wrote the manuscript and are responsible for its decision. Each of us fulfills the definition of authorship as stated by the International Committee of Medical Journal Editors ( www.icmje.org). We have signed and approved the final manuscript. Neither the manuscript, nor any essential part thereof, including tables and figures, will be published or accepted for refereeing elsewhere before being published in the Journal. We have also read the "Conflict of Interest" section and would disclose any existing. We state that if our manuscript is published in the RAC, we shall transfer the copyright to the Journal.

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eng

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info:eu-repo/semantics/publishedVersion