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F, ~g~1 EyjBI^|*4CgRhC \hwBr _$^/غEE~>W||ɧ|QO<ϓ^O:=NO=m#|oU9</xLq8I(yēO>v@_ˇmH"=i}Vq^' CGŻD&).bU ubX#b@􋜈w:|q.JgMsZ5N= }8N.g$`yJ_H83/Fgk[8zO$ȟKæEĻxo[P~pٮI+zA'ϥ Co/ =0^^$kTDppг$I8MN][v]8ܮ:jWv5^g]a`Y4Mb&5-:fBqňe-+M#&q#s)5;#\긫WJ endstream endobj 1494 0 obj <>/Filter/FlateDecode/ID[<0B20AFF90F16C745A7196F432DEDE214><90E511D80FEC414F89372B4A4219AED5>]/Info 108 0 R/Length 684/Root 1457 0 R/Size 1495/Type/XRef/W[1 3 1]>>stream h_HQ1J"b`eB咂Y`/Dzʇ 0^ JDS2z^[d͈mP) {=qT1Efe?]#JY=O7 zS"g+bѤ<8> ݕ^W]6z۷'w~#Obn͑ܯbq7&ٞgh]y~ 0. endstream endobj startxref 315494 %%EOF La rosuvastatina atenúa la progresión de la estenosis aórtica generada por hipertensión arterial, independientemente de sus efectos hipolipemiantes. - Archivo PPCT

La rosuvastatina atenúa la progresión de la estenosis aórtica generada por hipertensión arterial, independientemente de sus efectos hipolipemiantes.;
Rosuvastatin Slows the Progression of Aortic Stenosis Caused by Hypertension Regardless of

Creators:Giunta, Gustavo, Guevara, Eduardo, Marziali, Leandro, Gomez Rosso, Leonardo, Meroño, Tomas, Favaloro, Roberto, Brites, Fernando, Cuniberti, Luis
2012-01-20

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IntroducciónExiste evidencia epidemiológica que vincula factores de riesgo cardiovascular con la estenosis valvular aórtica. Recientemente se ha demostrado el desarrollo de estenosis valvular aórtica en un modelo de hipertensión arterial en animales. Planteamos la hipótesis de que el tratamiento con rosuvastatina modifica esta ransformación.ObjetivoEvaluar el efecto de la rosuvastatina sobre el desarrollo de estenosis valvular aórtica.Material y métodosSe instrumentaron conejos NZ machos (n = 43) con el modelo 1-riñón 1-clip de Goldblatt para generar hipertensión arterial. Los animales fueron aleatorizados a: HT (n = 17) que no recibió otro tratamiento, HT+R (n = 14) tratado con rosuvastatina 2,5 mg/kg/día y HT+R+C (n = 12) tratado con rosuvastatina 2,5 mg/kg/día + suplemento de colesterol dietético para mantener los niveles basales de colesterol plasmático. Un grupo control (GC) fue sometido a cirugía simulada (n = 15). Las características de la válvula aórtica se midieron por ecografía en condiciones basales y a los 3 y a los 6 meses de hipertensión arterial.ResultadosA los 6 meses de seguimiento, los incrementos de PAS y PAD fueron más elevados en HT (49% y 40%, respectivamente; p &lt; 0,001) en comparación con los grupos tratados con rosuvastatina (PAS = 23% y 25%; PAD = 28% y 26%; p &lt; 0,001 para HT+R y HT+R+C, respectivamente). El colesterol total se redujo el 45,7% (p &lt; 0,01) sólo en HT+R. El espesor valvar se incrementó en HT (0,50 ± 0,01 ConclusionesLa rosuvastatina atenúa la progresión de la estenosis valvular aórtica generada por hipertensión arterial. Esta protección podría ser mediada por efectos no hipolipemiantes de estas drogas.vs.  0,62 ± 0,02 mm; p &lt; 0,01), sin mostrar diferencias en HT+R y HT+R+C. Finalmente, el área valvular aórtica mostró una reducción en HT (0,277 ± 0,024 vs. 0,208 ± 0,014 cm2 ; p &lt; 0,05), sin cambios en HT+R y HT+R+C y un aumento no significativo en el GC (0,264 ± 0,022 vs. 0,32 ± 0,016 cm2 ; p = 0,07).

BackgroundThere is epidemiological evidence associating cardiovascular risk factors with aortic valve stenosis. The development of aortic valve stenosis has been recently demonstrated in a hypertensive animal model. We hypothesize that treatment with rosuvastatin modifies this transformation.ObjectiveTo evaluate the effect of rosuvastatin on the development of aortic valve stenosis. Material and MethodsHypertension was induced in 43 male NZ rabbits by a onekidney, one-clip Goldblatt procedure. The animals were randomly randomly assigned to 3 groups: HT (n=17) without treatment; HT+R (n=14) treated with rosuvastatin 2.5 mg/kg/day and HT+R+C (n=12) treated with rosuvastatin 2.5 mg/kg/day + cholesterol-enriched diet to keep baseline cholesterol levels. A control group (CG) underwent sham surgery (n=15). The characteristics of the aortic valve were measured by echocardiography at baseline, 3 and 6 months after inducing hypertension.Results After 6 months of follow-up, SBP and DBP presented greater increase in the group HT (49% and 40%, respectively; p &lt;0.001) compared to groups treated with rosuvastatin (SBP = 23% and 25%; DBP = 28% and 26%; p &lt;0.001 for HT+R and HT+R+C, respectively). Total cholesterol decreased by 45.7% (p &lt;0.01) only in HT+R group. The aortic valve became thickened in the HT group (0.50 ± 0.01 vs. 0.62 ± 0.02 mm; p &lt;0.01); there were no significant differences in HT+R and HT+R+C. Finally, the aortic valve area was reduced in HT (0.277 ± 0.024 vs. 0.208 ± 0.014 cm 2 ; p &lt;0.05), had no differences in HT+R and HT+R+C, and presented a non-significant increase in CG (0.264 ± 0.022 vs. 0.32 ± 0.016 cm 2 ; p=0.07).ConclusionsRosuvastatin slows the progression of aortic valve stenosis caused by hypertension. This protection might be independent of the lipid-lowering effect of the drug.

Metadatos destacados

Colecciones
Argentine Journal of Cardiology

Editor

Sociedad Argentina de Cardiología

Fuente

Revista Argentina de Cardiología; Vol 80, No 1 (2012), Argentine Journal of Cardiology; Vol 80, No 1 (2012)

Citación

Giunta, Gustavo et al., “La rosuvastatina atenúa la progresión de la estenosis aórtica generada por hipertensión arterial, independientemente de sus efectos hipolipemiantes.,” Archivo PPCT, consulta 2 de abril de 2026, http://archivoppct.caicyt.gov.ar/items/show/8040.

Dublin Core

Materia

Autor

Giunta, Gustavo
Guevara, Eduardo
Marziali, Leandro
Gomez Rosso, Leonardo
Meroño, Tomas
Favaloro, Roberto
Brites, Fernando
Cuniberti, Luis

Fuente

Revista Argentina de Cardiología; Vol 80, No 1 (2012)
Argentine Journal of Cardiology; Vol 80, No 1 (2012)

Editor

Sociedad Argentina de Cardiología

Fecha

2012-01-20

Derechos

Los que firman al pié, certificamos que tenemos total responsabilidad por la conducción de este estudio y por el diseño y la interpretación de los datos. Nosotros escribimos el manuscrito y somos responsables por la decisión acerca del mismo. Cada uno de nosotros cumple la definición de autor como se afirma en el Comité Internacional de Editores de Revistas Médicas (International Committee of Medical Journal Editors, ver www.icmje.org). Nosotros hemos visto y aprobado el manuscrito final. Ni el artículo, ni ninguna parte esencial del mismo, incluido las tablas y las figuras, será publicado o admitido para arbitrar a otra parte antes de aparecer en la Revista.También notificamos haber leído la sección “conflicto de intereses”, y revelaríamos cualquiera que existiera. Dejamos constancia que si nuestro artículo se publicara en la RAC, cederíamos los derechos (copyright) a la Revista.Los documentos publicados en esta revista están bajo la licencia Creative Commons Atribución-NoComercial-Compartir-Igual 2.5 Argentina.
Those signing below certify that we have full responsibility for the conduction of this study and for the design and interpretation of the information. We wrote the manuscript and are responsible for its decision. Each of us fulfills the definition of authorship as stated by the International Committee of Medical Journal Editors ( www.icmje.org). We have signed and approved the final manuscript. Neither the manuscript, nor any essential part thereof, including tables and figures, will be published or accepted for refereeing elsewhere before being published in the Journal. We have also read the "Conflict of Interest" section and would disclose any existing. We state that if our manuscript is published in the RAC, we shall transfer the copyright to the Journal.

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Idioma

spa
eng

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info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion