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Integración de marcadores humorales, ecocardiograma Doppler convencional y strain bidimensional sistólico en la detección de toxicidad miocárdica secundaria a la quimioterapia;
Serum Markers, Conventional Doppler Echocardiography and Two-dimensional Systolic Strain in the Diagnosis of Chemotherapy-Induced Myocardial Toxicity

Creators:Baratta, Sergio; Revista de la Sociedad Argentina de Cardiología, Damiano, Mario Atilio, Marchese, María Laura, Trucco, José Ignacio, Rizzo, Manglio Miguel, Bernok, Flavia, Chejtman, Demián, Olano, Daniel, Rojas, Mercedes, Hita, Alejandro
2013-06-14

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Descripción

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Background Left ventricular dysfunction is a serious complication of antineoplastic treatment with unfavorable impact in future clinical outcome. Early diagnosis of cardiotoxicity in patients receiving chemotherapy might be useful to define a strategy for the prevention of ventricular function impairment. Objective The aim of this study was to analyze the usefulness of serum markers (troponin T (TnT), BNP and NT-proBNP) and two-dimensional systolic longitudinal (LS) and radial (RS) strain to detect ventricular systolic dysfunction in patients treated with cardiotoxic chemotherapy. Methods Thirty six patients (average age (±SD) 47±16 years, 42% men), with neoplastic disease with normal myocardial mass and left ventricular ejection fraction (LVEF) ≥55% receiving chemotherapy treatment, were prospectively included. Assessment of serum markers and echocardiography were performed before chemotherapy and at 2, 3, 4 and 6 months after onset of cancer treatment. The 6-month cardiotoxicity endpoint (EP) was defined as reduced LVEF according to international consensus. Results Seven patients reached the EP (19.4%). Endpoint predictors were: NT-proBNP at 4 months (positive EP (G1): 152 ±42 pg/ml vs. negative EP (G2) 61±38 pg/ml, p&lt; 0.001), BNP at 4 months (G1 41±12 pg/ml vs. G2 26±11 pg/ml, p&lt; 0.01), twodimensional LS at 3 months (G1 16.3±2.4% vs. G2 19.6±2.02%, p&lt; 0.01) and 4 months (G1 15.9±1.77% vs. G2 19.9±2.2%, p&lt; 0.001), and two-dimensional RS at 4 months (G1 46.4±2.4% vs. G2 52±3.4%, p&lt; 0.001). Conclusions Natriuretic peptides and two-dimensional systolic LS and RS were useful to predict mild ventricular systolic dysfunction in chemotherapy-treated patients.

Metadatos destacados

Colecciones
Argentine Journal of Cardiology

Editor

Sociedad Argentina de Cardiología

Fuente

Revista Argentina de Cardiología; Vol 81, No 2 (2013); 133-138, Argentine Journal of Cardiology; Vol 81, No 2 (2013); 133-138

Citación

Baratta, Sergio; Revista de la Sociedad Argentina de Cardiología et al., “Integración de marcadores humorales, ecocardiograma Doppler convencional y strain bidimensional sistólico en la detección de toxicidad miocárdica secundaria a la quimioterapia,” Archivo PPCT, consulta 2 de abril de 2026, http://archivoppct.caicyt.gov.ar/items/show/8232.

Dublin Core

Materia

Autor

Baratta, Sergio; Revista de la Sociedad Argentina de Cardiología
Damiano, Mario Atilio
Marchese, María Laura
Trucco, José Ignacio
Rizzo, Manglio Miguel
Bernok, Flavia
Chejtman, Demián
Olano, Daniel
Rojas, Mercedes
Hita, Alejandro

Fuente

Revista Argentina de Cardiología; Vol 81, No 2 (2013); 133-138
Argentine Journal of Cardiology; Vol 81, No 2 (2013); 133-138

Editor

Sociedad Argentina de Cardiología

Fecha

2013-06-14

Derechos

Los que firman al pié, certificamos que tenemos total responsabilidad por la conducción de este estudio y por el diseño y la interpretación de los datos. Nosotros escribimos el manuscrito y somos responsables por la decisión acerca del mismo. Cada uno de nosotros cumple la definición de autor como se afirma en el Comité Internacional de Editores de Revistas Médicas (International Committee of Medical Journal Editors, ver www.icmje.org). Nosotros hemos visto y aprobado el manuscrito final. Ni el artículo, ni ninguna parte esencial del mismo, incluido las tablas y las figuras, será publicado o admitido para arbitrar a otra parte antes de aparecer en la Revista.También notificamos haber leído la sección “conflicto de intereses”, y revelaríamos cualquiera que existiera. Dejamos constancia que si nuestro artículo se publicara en la RAC, cederíamos los derechos (copyright) a la Revista.Los documentos publicados en esta revista están bajo la licencia Creative Commons Atribución-NoComercial-Compartir-Igual 2.5 Argentina.
Those signing below certify that we have full responsibility for the conduction of this study and for the design and interpretation of the information. We wrote the manuscript and are responsible for its decision. Each of us fulfills the definition of authorship as stated by the International Committee of Medical Journal Editors ( www.icmje.org). We have signed and approved the final manuscript. Neither the manuscript, nor any essential part thereof, including tables and figures, will be published or accepted for refereeing elsewhere before being published in the Journal. We have also read the "Conflict of Interest" section and would disclose any existing. We state that if our manuscript is published in the RAC, we shall transfer the copyright to the Journal.

Formato

Idioma

spa
eng

Tipo

info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion