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Relación de los polimorfismos G-174C, G-572C de la Interleucina-6 y C-511T, C+3953T de la Interluecina-1 con cardiopatía isquémica en Quito, Ecuador.;
Relationship of Interleukin-6 G-174C and G-572C and Interleukin-1 C-511T and C+3953T Polymorphisms with Ischemic Heart Disease in Quito, Ecuador

Creators:Colina Cifuentes, Rosa Inés; Laboratorio de Investigación en Biología Molecular, Facultad de Medicina, Pontificia Universidad Católica del Ecuador, Cárdenas Argüello, Luis Alejandro; Laboratorio de Investigación en Biología Molecular, Facultad de Medicina, Pontificia Universidad Católica del Ecuador, Guzman Clavijo, Edwin Roberto; Hospital Carlos Andrade Marín, Espinoza de los Moneteros Duche, Rommel Oswaldo; Hospital de las Fuerzas Armadas N1, Cruz Murillo, Fabian Santiago; Pontificia Universidad Católica del Ecuador, Caiza Llumiquinga, Fátima Leticia; Pontificia Universidad Católica del Ecuador
2019-04-11

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Descripción

Introducción: En los últimos años se ha evidenciado que los procesos inflamatorios están directamente relacionados con la formaciónde la placa ateroesclerótica, causante de la cardiopatía isquémica (CI). Por esta razón, toda molécula relacionada con aquellos procesoses de vital importancia. Las interleucinas (IL) son citoquinas proinflamatorias y sus polimorfismos aparentemente incrementanel proceso inflamatorio. Los más asociados con la cardiopatía isquémica son algunos polimorfismos de las interleucinas 1 (IL-1)y 6 (IL-6).Objetivos: Establecer la relación de los polimorfismos G-174C y G-572C de la interleucina-6 y C-511T y C+3953T de la interleucina-1 con la cardiopatía isquémica.Material y métodos: Se desarrolló un estudio de tipo analítico retrospectivo, de 76 casos y 76 controles, de pacientes atendidos enel servicio de hemodinámica del Hospital Carlos Andrade Marín (HCAM), de Quito. La genotipificación se hizo mediante la reacciónen cadena de la polimerasa con enzimas de restricción (PCR-RFLP).Resultados: De los cuatro polimorfismos estudiados, únicamente el IL-6174 GG tuvo una asociación estadísticamente significativacon la cardiopatía isquémica. La regresión logística usada para determinar los predictores más importantes de cardiopatía isquémicamostró que el genotipo IL-6 174 GG (OR 4,065, p=&lt;0,001) se asoció con un incremento del riesgo de presentar cardiopatía isquémicade forma independiente.Conclusiones: El genotipo GG del polimorfismo IL-6 G-174C confiere un riesgo 4 veces superior de desarrollar cardiopatía isquémica,mientras que los tres polimorfismos restantes no confieren riesgos.

Background: It has been recently found that inflammatory processes are directly related to the development of atheroscleroticplaque, causing ischemic heart disease. For this reason, every molecule related to these processes is critically important. Interleukins(IL) are proinflammatory cytokines, and their polymorphisms seem to increase the inflammatory progress. IL-1 and IL-6 polymorphismsare the ones most significantly associated with ischemic heart disease.Objectives: The aim of this study was to establish the relationship of IL-6 G-174C and G-572 C and IL-1 C-511T and C+3953Tpolymorphisms with ischemic heart disease.Methods: A retrospective study of 76 cases and 76 controls was carried out in patients attending the hemodynamics service of CarlosAndrade Marín Hospital (HCAM) of Quito, Ecuador. Genotyping was done on the basis of polymerase chain reaction with restrictionenzymes (PCR-RFLP).Results: Among the four polymorphisms studied, only IL-6 -174 GG was significantly associated with ischemic heart disease. Thelogistic regression analysis used to determine the most important predictors of ischemic heart disease showed that the IL-6 -174 GGgenotype was associated with an increased risk of independently presenting ischemic heart disease (OR 4.065, p ≤0.001).Conclusions: The GG genotype of IL-6 G-174C polymorphism confers a fourfold higher risk of developing ischemic heart disease,while the remaining three polymorphisms do not pose risks in this human population.

Metadatos destacados

Colecciones
Argentine Journal of Cardiology

Editor

Sociedad Argentina de Cardiología

Fuente

Revista Argentina de Cardiología; Vol 87, No 2 (2019); 98-102, Argentine Journal of Cardiology; Vol 87, No 2 (2019); 98-102

Citación

Colina Cifuentes, Rosa Inés; Laboratorio de Investigación en Biología Molecular, Facultad de Medicina, Pontificia Universidad Católica del Ecuador et al., “Relación de los polimorfismos G-174C, G-572C de la Interleucina-6 y C-511T, C+3953T de la Interluecina-1 con cardiopatía isquémica en Quito, Ecuador.,” Archivo PPCT, consulta 2 de abril de 2026, http://archivoppct.caicyt.gov.ar/items/show/8328.

Dublin Core

Autor

Colina Cifuentes, Rosa Inés; Laboratorio de Investigación en Biología Molecular, Facultad de Medicina, Pontificia Universidad Católica del Ecuador
Cárdenas Argüello, Luis Alejandro; Laboratorio de Investigación en Biología Molecular, Facultad de Medicina, Pontificia Universidad Católica del Ecuador
Guzman Clavijo, Edwin Roberto; Hospital Carlos Andrade Marín
Espinoza de los Moneteros Duche, Rommel Oswaldo; Hospital de las Fuerzas Armadas N1
Cruz Murillo, Fabian Santiago; Pontificia Universidad Católica del Ecuador
Caiza Llumiquinga, Fátima Leticia; Pontificia Universidad Católica del Ecuador

Fuente

Revista Argentina de Cardiología; Vol 87, No 2 (2019); 98-102
Argentine Journal of Cardiology; Vol 87, No 2 (2019); 98-102

Editor

Sociedad Argentina de Cardiología

Fecha

2019-04-11

Colaborador

Pontificia Universidad Católica del Ecuador

Derechos

Los que firman al pié, certificamos que tenemos total responsabilidad por la conducción de este estudio y por el diseño y la interpretación de los datos. Nosotros escribimos el manuscrito y somos responsables por la decisión acerca del mismo. Cada uno de nosotros cumple la definición de autor como se afirma en el Comité Internacional de Editores de Revistas Médicas (International Committee of Medical Journal Editors, ver www.icmje.org). Nosotros hemos visto y aprobado el manuscrito final. Ni el artículo, ni ninguna parte esencial del mismo, incluido las tablas y las figuras, será publicado o admitido para arbitrar a otra parte antes de aparecer en la Revista.También notificamos haber leído la sección “conflicto de intereses”, y revelaríamos cualquiera que existiera. Dejamos constancia que si nuestro artículo se publicara en la RAC, cederíamos los derechos (copyright) a la Revista.Los documentos publicados en esta revista están bajo la licencia Creative Commons Atribución-NoComercial-Compartir-Igual 2.5 Argentina.
Those signing below certify that we have full responsibility for the conduction of this study and for the design and interpretation of the information. We wrote the manuscript and are responsible for its decision. Each of us fulfills the definition of authorship as stated by the International Committee of Medical Journal Editors ( www.icmje.org). We have signed and approved the final manuscript. Neither the manuscript, nor any essential part thereof, including tables and figures, will be published or accepted for refereeing elsewhere before being published in the Journal. We have also read the "Conflict of Interest" section and would disclose any existing. We state that if our manuscript is published in the RAC, we shall transfer the copyright to the Journal.

Idioma

spa
eng

Tipo

info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion