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U? 1= * endstream endobj 30 0 obj <>stream h2T0Pw.JM,sI,Ip2204142bCcK]cuuM" ǔT<<`S s=MM}tC, 委&L pqSL*J,TԳ)J,(HMwK)N0(B- endstream endobj 31 0 obj <>/Filter/FlateDecode/ID[<18564ABF2A14574A9BC70645BB1E6526><54E477AF02D3304F85CEAE6DA64CCB59>]/Info 589 0 R/Length 183/Root 591 0 R/Size 590/Type/XRef/W[1 3 1]>>stream hbb&FF L@Y)-".H =D/lB` Rf'}LvH(ɰ^LH`5 D]c l>?3f^0W@If0 &GQ$pp%G(9Ft5J!L" [ endstream endobj startxref 116 %%EOF Valor pronóstico del índice leucoglucémico en el infarto agudo de miocardio. Resultados del Registro Multicéntrico SCAR - Archivo PPCT

Valor pronóstico del índice leucoglucémico en el infarto agudo de miocardio. Resultados del Registro Multicéntrico SCAR;
Prognostic Value of the Leuko-glycemic Index in Acute Myocardial Infarction. Results from the SCAR Multicenter Registry

Creators:Hirschson Prado, Alfredo; Revista de la Sociedad Argentina de Cardiología, Higa, Claudio, Merlo, Pablo, Domine, Enrique, Blanco, Patricia, Vázquez, Gastón A., Cohen Arazi, Hernán, Benzadón, Mariano
2014-12-23

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Descripción

Objetivos: Analizar el valor pronostico del índice leucoglucemico (iLG) en los pacientes con síndromes coronarios agudos con supradesnivel del segmento ST (SCACEST) y evaluar su valor agregado a los scores clásicos de riesgo. Material y Métodos: se analizaron a los pacientes con diagnostico de IAM con supradesnivel del segmento ST (IAMCEST) del registro SCAR (Síndromes Coronarios Agudos en Argentina). El punto final analizado fue la muerte y desarrollo de Killip 3/4 en el periodo hospitalario. Se analizo el iLG tanto como variable continua como en cuartilos según los valores de percentilos 25, 50 y 75. Resultados: se analizaron 405 de 758 pts con diagnostico final de IAMCEST. La presencia del punto final fue significativamente creciente por cuartilos de iLG: 0%, 7,6%, 9,3% y 30.6%, p&lt;0.0001. El área bajo la curva ROC del iLG para el punto final combinado fue de 0.77 (IC 95% 0.71-0.88), p 0.0001, el mejor valor de corte pronostico fue de 1000. La presencia de muerte/killip 3/4 fue de 0% y de 13% en los IAMCEST con iLG menor y mayor de 1000, respectivamente. En un modelo de regresión logística multivariado, el iLG se asocio independientemente  a muerte/killip 3/4. El área bajo la curva ROC del score de TIMI para IAMCEST fue de 0,58. El agregado del iLG incremento su capacidad discriminatoria a 0,66 (p 0.001) Conclusiones: el iLG demostró ser un predictor independiente de mala evolución en el IAMCEST (muerte/insuficiencia cardiaca grave), con valor aditivo al Score de TIMI

Background: Leukocytosis and hyperglycemia correlate with worse short-term prognosis in patients with acute coronarysyndrome, but their new relationship, called leuko-glycemic index (LGI), has been scarcely evaluated.Objectives: The aim of this study was to analyze the prognostic value of LGI in patients with ST-segment-elevation acutemyocardial infarction (STEMI) and its added value to classical risk scores.Methods: Patients diagnosed with STEMI from the SCAR (Acute Coronary Syndromes in Argentina) Multicenter Registrywere analyzed. The final endpoint was death or in-hospital Killip-Kimball 3-4 (KK 3-4). The LGI was analyzed as a continuousvariable and in quartiles according to 25, 50 and 75 percentile values.Results: The study evaluated 405 out of 476 patients with final STEMI diagnosis. Presence of the primary endpoint significantlyincreased per LGI quartile: 0%, 7.60%, 9.30% and 30.60% (p &lt; 0.0001). The LGI area under the ROC curve for the compositeendpoint was 0.77 [(95% CI 0.71-0.88); p = 0.0001]; the best prognostic cut-off value was 1000. Presence of death or KK 3-4was 0% and 13% in STEMI patients with LGI below or above 1000, respectively. In a multivariate logistic regression model,LGI was independently associated with death or KK 3-4. The area under the ROC curve of the TIMI risk score for STEMIwas 0.58. The addition of LGI increased its discriminatory capacity to 0.66 (p = 0.001).Conclusions: The LGI was an independent predictor of adverse outcome in STEMI patients (death or KK 3-4), adding prognosticvalue to the TIMI risk score.

Metadatos destacados

Colecciones
Argentine Journal of Cardiology

Editor

Sociedad Argentina de Cardiología

Fuente

Revista Argentina de Cardiología; Vol 82, No 6 (2014); 500-505, Argentine Journal of Cardiology; Vol 82, No 6 (2014); 500-505

Citación

Hirschson Prado, Alfredo; Revista de la Sociedad Argentina de Cardiología et al., “Valor pronóstico del índice leucoglucémico en el infarto agudo de miocardio. Resultados del Registro Multicéntrico SCAR,” Archivo PPCT, consulta 2 de abril de 2026, http://archivoppct.caicyt.gov.ar/items/show/8379.

Dublin Core

Autor

Hirschson Prado, Alfredo; Revista de la Sociedad Argentina de Cardiología
Higa, Claudio
Merlo, Pablo
Domine, Enrique
Blanco, Patricia
Vázquez, Gastón A.
Cohen Arazi, Hernán
Benzadón, Mariano

Fuente

Revista Argentina de Cardiología; Vol 82, No 6 (2014); 500-505
Argentine Journal of Cardiology; Vol 82, No 6 (2014); 500-505

Editor

Sociedad Argentina de Cardiología

Fecha

2014-12-23

Derechos

Los que firman al pié, certificamos que tenemos total responsabilidad por la conducción de este estudio y por el diseño y la interpretación de los datos. Nosotros escribimos el manuscrito y somos responsables por la decisión acerca del mismo. Cada uno de nosotros cumple la definición de autor como se afirma en el Comité Internacional de Editores de Revistas Médicas (International Committee of Medical Journal Editors, ver www.icmje.org). Nosotros hemos visto y aprobado el manuscrito final. Ni el artículo, ni ninguna parte esencial del mismo, incluido las tablas y las figuras, será publicado o admitido para arbitrar a otra parte antes de aparecer en la Revista.También notificamos haber leído la sección “conflicto de intereses”, y revelaríamos cualquiera que existiera. Dejamos constancia que si nuestro artículo se publicara en la RAC, cederíamos los derechos (copyright) a la Revista.Los documentos publicados en esta revista están bajo la licencia Creative Commons Atribución-NoComercial-Compartir-Igual 2.5 Argentina.
Those signing below certify that we have full responsibility for the conduction of this study and for the design and interpretation of the information. We wrote the manuscript and are responsible for its decision. Each of us fulfills the definition of authorship as stated by the International Committee of Medical Journal Editors ( www.icmje.org). We have signed and approved the final manuscript. Neither the manuscript, nor any essential part thereof, including tables and figures, will be published or accepted for refereeing elsewhere before being published in the Journal. We have also read the "Conflict of Interest" section and would disclose any existing. We state that if our manuscript is published in the RAC, we shall transfer the copyright to the Journal.

Formato

Idioma

eng
spa

Tipo

info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion