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FEOCROMOCITOMA Y PARAGANGLIOMAS:EXPERIENCIA DE UN HOSPITAL DE BUENOS AIRES;
Pheochromocytomas and Paragangliomas: Experience of a Buenos Aires General Hospital

Creators:Santoro, Silvina, Palma, Yandri, Barontini, Marta, Amicucci, Roberto, Lamy, Roberto, Lupi, Susana
2015-05-07

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Descripción

Objetivo: Describir la casuística de feocromocitomas (FC) y paragangliomas (PG) seguidos en la División Endocrinología del Hospital Gral. De Agudos J.M. Ramos Mejía desde 1994 a la actualidad. Materiales y métodos: Análisis retrospectivo de las historias clínicas entre 1994 y 2014 Resultados: Veintidós pacientes fueron diagnosticados y tratados,  17 mujeres y 5 varones, con una edad media al diagnóstico de 41,2 años (17-65). Dieciséis presentaron signo-sintomatología habitual. Dos necrosis isquémicas de miembros, y 4 se presentaron normotensos, 3 como incidentalomas y uno con hiperglucemia y astenia.  Todos los pacientes presentaron catecolaminas, metanefrinas urinarias y/o ácido vainillín mandélico elevados. Doce pacientes presentaron localización adrenal única (8 derecha y 4 izquierda),  5 fueron  bilaterales, y 5 extra-adrenales. Diez pacientes fueron portadores de síndromes familiares: 4 MEN 2 A, 2 VHL y 4 paragangliomas por mutación de la SHDB. Once pacientes fueron operados por vía laparoscópica y 11 convertidos a convencional por tamaño o sangrado. En 59% se evidencio hipertensión intraquirúrgica y 19 pacientes evolucionaron con hipotensión en el postquirúrgico inmediato. En el seguimiento ulterior, cuatro pacientes presentaron recurrencia bioquímica de su enfermedad, dos de ellos requirieron una segunda cirugía por persistencia local de la enfermedad, uno presento enfermedad metastasica irresecable con óbito, y otra recurrencia bioquímica marginal sin localización a la fecha. Conclusiones: Reportamos nuestra experiencia institucional en el manejo de FC y PG, reforzando que  abordaje multidisciplinario es esencial para disminuir la elevada morbimortalidad de esta patología.

We report pheochromocytoma and paraganglioma case studies followed-up in the Hospital General de Agudos “José M. RamosMejía” Division of Endocrinology between 1994 and 2014. Twenty two patients were diagnosed and treated, 17 womenand 5 men. Sixteen patients presented with typical signs and symptoms, 2 had associated ischemic limb necrosis, and 4 werenormotensive (3 with incidentalomas and 1 with hyperglycemia and asthenia). Elevated urinary catecholamine and metanephrinelevels were found in all patients. Twelve patients exhibited unilateral adrenal disease (8 right and 4 left), 5 hadbilateral disease and 5 extra-adrenal disease Ten patients had familial syndromes. Eleven patients underwent laparoscopicsurgery and 11 required conversion to laparotomy due to tumor size or bleeding. During follow-up, biochemical recurrencewas observed in four patients, two with local recurrence, one with metastasis, and one with untraceable tumor). This reportof our institutional experience emphasizes the importance of a multidisciplinary approach to treat this disease.

Metadatos destacados

Colecciones
Argentine Journal of Cardiology

Editor

Sociedad Argentina de Cardiología

Fuente

Revista Argentina de Cardiología; Vol 83, No 2 (2015); 136-140, Argentine Journal of Cardiology; Vol 83, No 2 (2015); 136-140

Citación

Santoro, Silvina et al., “FEOCROMOCITOMA Y PARAGANGLIOMAS:EXPERIENCIA DE UN HOSPITAL DE BUENOS AIRES,” Archivo PPCT, consulta 4 de abril de 2026, http://archivoppct.caicyt.gov.ar/items/show/8671.

Dublin Core

Materia

Autor

Santoro, Silvina
Palma, Yandri
Barontini, Marta
Amicucci, Roberto
Lamy, Roberto
Lupi, Susana

Fuente

Revista Argentina de Cardiología; Vol 83, No 2 (2015); 136-140
Argentine Journal of Cardiology; Vol 83, No 2 (2015); 136-140

Editor

Sociedad Argentina de Cardiología

Fecha

2015-05-07

Derechos

Los que firman al pié, certificamos que tenemos total responsabilidad por la conducción de este estudio y por el diseño y la interpretación de los datos. Nosotros escribimos el manuscrito y somos responsables por la decisión acerca del mismo. Cada uno de nosotros cumple la definición de autor como se afirma en el Comité Internacional de Editores de Revistas Médicas (International Committee of Medical Journal Editors, ver www.icmje.org). Nosotros hemos visto y aprobado el manuscrito final. Ni el artículo, ni ninguna parte esencial del mismo, incluido las tablas y las figuras, será publicado o admitido para arbitrar a otra parte antes de aparecer en la Revista.También notificamos haber leído la sección “conflicto de intereses”, y revelaríamos cualquiera que existiera. Dejamos constancia que si nuestro artículo se publicara en la RAC, cederíamos los derechos (copyright) a la Revista.Los documentos publicados en esta revista están bajo la licencia Creative Commons Atribución-NoComercial-Compartir-Igual 2.5 Argentina.
Those signing below certify that we have full responsibility for the conduction of this study and for the design and interpretation of the information. We wrote the manuscript and are responsible for its decision. Each of us fulfills the definition of authorship as stated by the International Committee of Medical Journal Editors ( www.icmje.org). We have signed and approved the final manuscript. Neither the manuscript, nor any essential part thereof, including tables and figures, will be published or accepted for refereeing elsewhere before being published in the Journal. We have also read the "Conflict of Interest" section and would disclose any existing. We state that if our manuscript is published in the RAC, we shall transfer the copyright to the Journal.

Formato

Idioma

spa
eng

Tipo

info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion