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Variaciones de los niveles plasmáticos de VEGF con el ejercicio en pacientes con enfermedad coronaria crónica;
Plasma VEGF Level Changes with Exercise in Patients with Chronic Coronary Artery Disease

Creators:Gagliardi, Juan; Hospital General de Agudos "Dr. Cosme Argerich"., Maciel, Neiva; Hospital General de Agudos "Dr. Cosme Argerich"., Castellano, José Luis; Hospital General de Agudos "Dr. Cosme Argerich"., Miksztowicz, Verónica; Laboratorio de Lípidos y Lipoproteínas del Departamento de Bioquímica Clínica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Berg, Gabriela; Laboratorio de Lípidos y Lipoproteínas del Departamento de Bioquímica Clínica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Gelpi, Ricardo J.; Instituto de Fisiopatología Cardiovascular, Facultad de Medicina, Universidad de Buenos Aires
2015-07-01

Colaborador:

  • Consejo de Investigación en Salud, Ministerio de Salud, Gobierno de la Ciudad de Buenos Aires

Materia:

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Descripción

Con el objetivo de evaluar el efecto del ejercicio físico agudo y programado sobre los niveles plasmáticos de VEGF en pacientescoronarios crónicos estables, se estudiaron 21 pacientes &lt; 75 años a los que luego de la evaluación basal se les realizó unestudio de perfusión miocárdica con esfuerzo (agudo) y posteriormente se asignaron en forma aleatoria a realizar ejerciciosprogramados de rehabilitación o continuar con el tratamiento habitual.Los valores de VEGF disminuyeron significativamente en el posesfuerzo de la ergometría de la SPECT (de 49,59 ± 6,06 a31,83 ± 5,62 pg/ml; p = 0,021). Al mes, los valores aumentaron (70,90 ± 14,44 pg/ml) con tendencia no significativa respectodel valor basal (p = 0,1) y significativamente respecto de los valores del posesfuerzo inmediato (p &lt; 0,01). No se observaroncambios significativos en los valores de VEGF a los 3 meses y tampoco al comparar los resultados según la presencia de isquemiao la realización de ejercicios programados.El ejercicio agudo indujo una reducción significativa en los valores de VEGF, sin diferencias entre el ejercicio programado yel grupo control.

The aim of this study was to assess the effect of acute and programmed physical exercise on plasma VEGF levels in chronicstable coronary artery disease patients. Following baseline evaluation, 21 patients &lt;75 years underwent a stress myocardialperfusion scan (acute), and were then randomly assigned to perform programmed rehabilitation exercise or continue withtheir normal therapy. VEGF assessed by SPECT imaging significantly decreased after stress ergometry (from 49.59±6.06 to31.83±5.62 pg/ml; p=0.021). At one month, it increased (70.90±14.44 pg/ml) though not significantly with respect to baselinevalues (p=0.1) and significantly with respect to immediate post-stress values (p&lt;0.01). No significant changes were observedin VEGF at 3 months or when results were compared according to the presence of ischemia or programmed exercise.Acute exercise induced a significant reduction in VEGF values, without differences between programmed exercise and thecontrol group.

Metadatos destacados

Colecciones
Argentine Journal of Cardiology

Editor

Sociedad Argentina de Cardiología

Fuente

Revista Argentina de Cardiología; Vol 83, No 3 (2015); 232-235, Argentine Journal of Cardiology; Vol 83, No 3 (2015); 232-235

Citación

Gagliardi, Juan; Hospital General de Agudos "Dr. Cosme Argerich". et al., “Variaciones de los niveles plasmáticos de VEGF con el ejercicio en pacientes con enfermedad coronaria crónica,” Archivo PPCT, consulta 2 de abril de 2026, http://archivoppct.caicyt.gov.ar/items/show/8857.

Dublin Core

Materia

Autor

Gagliardi, Juan; Hospital General de Agudos "Dr. Cosme Argerich".
Maciel, Neiva; Hospital General de Agudos "Dr. Cosme Argerich".
Castellano, José Luis; Hospital General de Agudos "Dr. Cosme Argerich".
Miksztowicz, Verónica; Laboratorio de Lípidos y Lipoproteínas del Departamento de Bioquímica Clínica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires
Berg, Gabriela; Laboratorio de Lípidos y Lipoproteínas del Departamento de Bioquímica Clínica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires
Gelpi, Ricardo J.; Instituto de Fisiopatología Cardiovascular, Facultad de Medicina, Universidad de Buenos Aires

Fuente

Revista Argentina de Cardiología; Vol 83, No 3 (2015); 232-235
Argentine Journal of Cardiology; Vol 83, No 3 (2015); 232-235

Editor

Sociedad Argentina de Cardiología

Fecha

2015-07-01

Colaborador

Consejo de Investigación en Salud, Ministerio de Salud, Gobierno de la Ciudad de Buenos Aires

Derechos

Los que firman al pié, certificamos que tenemos total responsabilidad por la conducción de este estudio y por el diseño y la interpretación de los datos. Nosotros escribimos el manuscrito y somos responsables por la decisión acerca del mismo. Cada uno de nosotros cumple la definición de autor como se afirma en el Comité Internacional de Editores de Revistas Médicas (International Committee of Medical Journal Editors, ver www.icmje.org). Nosotros hemos visto y aprobado el manuscrito final. Ni el artículo, ni ninguna parte esencial del mismo, incluido las tablas y las figuras, será publicado o admitido para arbitrar a otra parte antes de aparecer en la Revista.También notificamos haber leído la sección “conflicto de intereses”, y revelaríamos cualquiera que existiera. Dejamos constancia que si nuestro artículo se publicara en la RAC, cederíamos los derechos (copyright) a la Revista.Los documentos publicados en esta revista están bajo la licencia Creative Commons Atribución-NoComercial-Compartir-Igual 2.5 Argentina.
Those signing below certify that we have full responsibility for the conduction of this study and for the design and interpretation of the information. We wrote the manuscript and are responsible for its decision. Each of us fulfills the definition of authorship as stated by the International Committee of Medical Journal Editors ( www.icmje.org). We have signed and approved the final manuscript. Neither the manuscript, nor any essential part thereof, including tables and figures, will be published or accepted for refereeing elsewhere before being published in the Journal. We have also read the "Conflict of Interest" section and would disclose any existing. We state that if our manuscript is published in the RAC, we shall transfer the copyright to the Journal.

Formato

Idioma

spa
eng

Tipo

info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

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crónica - Archivo PPCT