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65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f trailer <]>> startxref 116 %%EOF Transplante Cardiaco con donantes cadavéricos: de la investigación a la práctica clínica - Archivo PPCT

Transplante Cardiaco con donantes cadavéricos: de la investigación a la práctica clínica;
Heart Transplantation Using Donors after Circulatory Death: From Research to Clinical Practice

Creators:Knop, Gustavo Lionel; Cirugia Cardiotoracica
2016-02-29

Colaborador:

  • Transmedics

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Descripción

Los donantes cadavericos para trasplante cardiacos se abandonaron desde la decada de 1970 con el advenimiento de la ley  de muerte cerebral ( cadaveres con corazon latiendo), en los cuales el Corazon se halla latiendo y perfundido hasta ultimo momento previo al explante. Pero la escasez de donantes ha reavivado el interes en la investigacion animal y clinica para utilizar donantes cadavericos para trasplante cardiaco, intentando optimizar la funcion cardiaca luego del period de deprivacion de oxigeno producido por la hipotension severa y posteriormente la detencion circulatoria.  Papworth Hospital ha realizado una investigacion clinica exitosa, efectuando ocho trasplantes cardiacos con donantes cadavericos sin mortalidad, y es el lider mundial en esta practica al momento. Se eligieron  recipientes de bajo riesgo,con consentimiento previo expreso.  Los donantes cadavericos fueron reperfundidos con el uso de dispositivo de circulacion extracorporea, y luego de ser destetados del apoyo circulatorio, el Corazon fue explantado y conectado  a la maquina de perfusion para ser trasladados y a la vez evaluados funcionalmente y luego implantados.

Donation after circulatory death for heart transplantation was abandoned in the 1970s with the advent of the brain death law (donation after brain death), where the donor heart is beating and perfused up to the moment prior to organ retrieval. Shortage of donors has renewed the interest in animal and clinical research of donors after circulatory death for heart transplantation, aiming at optimizing heart function after the period of oxygen deprivation caused by severe hypotension and subsequent circulatory arrest. This study presents the initial experience with donation after circulatory death for heart transplantation at our institution. Papworth Hospital has performed a successful clinical investigation in which ten cardiac transplants were performed with hearts from donation after circulatory death, without mortality. Low risk recipients who had previously signed their consent were chosen. Most hearts from donation after circulatory death were reperfused with an extracorporeal circulation device, and following weaning from the circulatory support the heart was harvested and connected to the perfusion machine for transportation and simultaneous assessment of function before implantation. In conclusion, this technique could be used for cardiac transplantation with satisfactory outcomes.

Metadatos destacados

Colecciones
Argentine Journal of Cardiology

Editor

Sociedad Argentina de Cardiología

Fuente

Revista Argentina de Cardiología; Vol 84, No 1 (2016); 59-63, Argentine Journal of Cardiology; Vol 84, No 1 (2016); 59-63

Citación

Knop, Gustavo Lionel; Cirugia Cardiotoracica, “Transplante Cardiaco con donantes cadavéricos: de la investigación a la práctica clínica,” Archivo PPCT, consulta 2 de abril de 2026, http://archivoppct.caicyt.gov.ar/items/show/8976.

Dublin Core

Autor

Knop, Gustavo Lionel; Cirugia Cardiotoracica

Fuente

Revista Argentina de Cardiología; Vol 84, No 1 (2016); 59-63
Argentine Journal of Cardiology; Vol 84, No 1 (2016); 59-63

Editor

Sociedad Argentina de Cardiología

Fecha

2016-02-29

Colaborador

Transmedics

Derechos

Los que firman al pié, certificamos que tenemos total responsabilidad por la conducción de este estudio y por el diseño y la interpretación de los datos. Nosotros escribimos el manuscrito y somos responsables por la decisión acerca del mismo. Cada uno de nosotros cumple la definición de autor como se afirma en el Comité Internacional de Editores de Revistas Médicas (International Committee of Medical Journal Editors, ver www.icmje.org). Nosotros hemos visto y aprobado el manuscrito final. Ni el artículo, ni ninguna parte esencial del mismo, incluido las tablas y las figuras, será publicado o admitido para arbitrar a otra parte antes de aparecer en la Revista.También notificamos haber leído la sección “conflicto de intereses”, y revelaríamos cualquiera que existiera. Dejamos constancia que si nuestro artículo se publicara en la RAC, cederíamos los derechos (copyright) a la Revista.Los documentos publicados en esta revista están bajo la licencia Creative Commons Atribución-NoComercial-Compartir-Igual 2.5 Argentina.
Those signing below certify that we have full responsibility for the conduction of this study and for the design and interpretation of the information. We wrote the manuscript and are responsible for its decision. Each of us fulfills the definition of authorship as stated by the International Committee of Medical Journal Editors ( www.icmje.org). We have signed and approved the final manuscript. Neither the manuscript, nor any essential part thereof, including tables and figures, will be published or accepted for refereeing elsewhere before being published in the Journal. We have also read the "Conflict of Interest" section and would disclose any existing. We state that if our manuscript is published in the RAC, we shall transfer the copyright to the Journal.

Formato

Idioma

eng
spa

Tipo

info:eu-repo/semantics/article
260
info:eu-repo/semantics/publishedVersion