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Efectos del ejercicio intenso sobre la hipertrofia miocárdica y la función ventricular en un modelo de ratón transgénico con hiperactividad simpática;
Effects of Endurance Training on Myocardial Hypertrophy and Ventricular Function in a Transgenic Mouse Model with Sympathetic Hyperactivity

Creators:Wilensky, Luciana; Dpto. de Patología, Facultad de Medicina, UBA. Pte. Uriburu 950, piso 2, CABA., Martínez Naya, Nadia, Kelly, Jazmín, Cassaglia, Pablo, Arruano, María E., Buchholz, Bruno, Mogunovsky Michell, Isaac L., Morales, Celina, González, Germán E.
2016-01-15

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Descripción

Introducción: En estudios previos mostramos que el ejercicio intenso (EI) reduce la reserva inotrópica, cronotrópica y lusitrópica enratones normales.Objetivo: Evaluar el efecto del ejercicio intenso sobre la reserva inotrópica y cronotrópica en un modelo de ratones transgénicos consobreexpresión cardíaca de la proteína Gsα, que induce un cuadro de hiperactividad simpática.Material y métodos: El ejercicio consistió en dos sesiones diarias de 90 minutos de natación, 6 días/semana durante 4 semanas. Seutilizaron cuatro grupos experimentales: 1: sedentario no transgénico (noTG Sed); 2: sedentario TG (TG Sed); 3: noTG+EI y 4:TG+EI.Resultados: El ejercicio indujo el desarrollo de hipertrofia miocárdica [índice peso del ventrículo izquierdo (g)/longitud de la tibia(mm)] desde 5,3±0,3 y 5,5±0,2 en noTG Sed y TG Sed a 6,8±0,1 y 6,8±0,3 en noTG+EI y TG+EI, respectivamente (p&lt;0,05 noTGSed vs. noTG+EI y TG Sed vs. TG+EI). La administración de isoproterenol (56 ng/kg) incrementó la +dP/dtmáx 63% ±10% ennoTG Sed (p&lt;0,05 vs. basal); 34% ±2% en TG Sed (p&lt;0,05 vs.basal y p&lt; 0,05 vs. noTG Sed); 36% ±7% en noTG+EI (p&lt;0,05 vs.basal) y 36% ±7% en TG+EI (p&lt;0,05 vs.basal). La frecuencia cardíaca aumentó de 301±15 a 528±37 latidos/min en noTG Sed(p&lt;0,05 vs. basal), de 519±57 a 603±41 latidos/min en TG Sed, de 300±16 a 375±20 en noTG+EI (p&lt;0,05 vs. basal) y de 484±18a 515±21 en TG+EI. El colágeno intersticial fue similar entre los grupos.Conclusiones: Estos resultados sugieren que el ejercicio intenso disminuye la reserva inotrópica y cronotrópica sin generar cambiosestructurales vinculados a la hipertrofia patológica. La presencia de hiperactividad simpática no modifica esta respuesta.

Metadatos destacados

Colecciones
Argentine Journal of Cardiology

Editor

Sociedad Argentina de Cardiología

Fuente

Revista Argentina de Cardiología; Vol 83, No 6 (2015); 511-515, Argentine Journal of Cardiology; Vol 83, No 6 (2015); 511-515

Citación

Wilensky, Luciana; Dpto. de Patología, Facultad de Medicina, UBA. Pte. Uriburu 950, piso 2, CABA. et al., “Efectos del ejercicio intenso sobre la hipertrofia miocárdica y la función ventricular en un modelo de ratón transgénico con hiperactividad simpática,” Archivo PPCT, consulta 1 de abril de 2026, http://archivoppct.caicyt.gov.ar/items/show/8987.

Dublin Core

Autor

Wilensky, Luciana; Dpto. de Patología, Facultad de Medicina, UBA. Pte. Uriburu 950, piso 2, CABA.
Martínez Naya, Nadia
Kelly, Jazmín
Cassaglia, Pablo
Arruano, María E.
Buchholz, Bruno
Mogunovsky Michell, Isaac L.
Morales, Celina
González, Germán E.

Fuente

Revista Argentina de Cardiología; Vol 83, No 6 (2015); 511-515
Argentine Journal of Cardiology; Vol 83, No 6 (2015); 511-515

Editor

Sociedad Argentina de Cardiología

Fecha

2016-01-15

Derechos

Los que firman al pié, certificamos que tenemos total responsabilidad por la conducción de este estudio y por el diseño y la interpretación de los datos. Nosotros escribimos el manuscrito y somos responsables por la decisión acerca del mismo. Cada uno de nosotros cumple la definición de autor como se afirma en el Comité Internacional de Editores de Revistas Médicas (International Committee of Medical Journal Editors, ver www.icmje.org). Nosotros hemos visto y aprobado el manuscrito final. Ni el artículo, ni ninguna parte esencial del mismo, incluido las tablas y las figuras, será publicado o admitido para arbitrar a otra parte antes de aparecer en la Revista.También notificamos haber leído la sección “conflicto de intereses”, y revelaríamos cualquiera que existiera. Dejamos constancia que si nuestro artículo se publicara en la RAC, cederíamos los derechos (copyright) a la Revista.Los documentos publicados en esta revista están bajo la licencia Creative Commons Atribución-NoComercial-Compartir-Igual 2.5 Argentina.
Those signing below certify that we have full responsibility for the conduction of this study and for the design and interpretation of the information. We wrote the manuscript and are responsible for its decision. Each of us fulfills the definition of authorship as stated by the International Committee of Medical Journal Editors ( www.icmje.org). We have signed and approved the final manuscript. Neither the manuscript, nor any essential part thereof, including tables and figures, will be published or accepted for refereeing elsewhere before being published in the Journal. We have also read the "Conflict of Interest" section and would disclose any existing. We state that if our manuscript is published in the RAC, we shall transfer the copyright to the Journal.

Formato

Idioma

eng
spa

Tipo

info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion