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0_`sI%R P :vI!IJZAtp>/Filter/FlateDecode/ID[<3DA9366BE99EAD438AD14AE24D708B5E>]/Info 253 0 R/Length 161/Root 255 0 R/Size 254/Type/XRef/W[1 3 1]>>stream hbb&FF L@{)!"A. &jtH2< = "Iw`5kA}l%``: DrH@i) /a`$LBaGQr$d;JWl`n endstream endobj startxref 116 %%EOF Efecto del déficit de galectina-3 sobre la remodelación ventricular posoclusión coronaria en ratones - Archivo PPCT

Efecto del déficit de galectina-3 sobre la remodelación ventricular posoclusión coronaria en ratones;
Effect of Galectin-3 Deficit on Ventricular Remodeling After Coronary Occlusion in Mice

Creators:Wilensky, Luciana, Martínez Naya, Nadia L., Cassaglia, Pablo, Volberg, Verónica, Tau, Julia, Aruanno, Eugenia, Morgunowsky Michell, Isaac, Morales, Celina, González, Germán E.; Dpto. de Patologia, Fac. de Medicina, UBA
Pte. Uriburu 950, piso 2, CABA.
2015-08-25

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Descripción

Galectina 3 (Gal-3) es una lectina que regula la respuesta inmune. Sin embargo, su rol en el remodelamiento y la función ventricular post-infarto de miocardio (IM) es desconocido. Estudiamos si el déficit de Gal-3 empeora el remodelamiento y la función ventricular post-IM en ratones. Se utilizaron ratones machos Gal-3 KO y su respectivo control C57 con ligadura de la coronaria descendente anterior o Sham. Se realizaron 4 grupos experimentales: C57 Sham, Gal-3 KO Sham, C57 IM y Gal-3 KO IM. A los 7 días post-cirugía, se les realizó ecocardiografía, autopsia, y se cuantificó el tamaño de IM y la fibrosis en cortes teñidos con tricrómico de Masson (TM) y picrosirius red (SR) respectivamente, y el infiltrado de macrófagos y la expresión de IL-6. Los diámetros del VI se incrementaron significativamente en el grupo C57 IM respecto al Sham y dicho incremento fue aun mayor en el grupo Gal-3 KO IM. Además, la fracción de eyección (FE) disminuyó desde 47 ± 2% a 37 ± 3% en en C57 IM y Gal-3 KO IM respectivamente (P&lt; 0.02). El tamaño de IM aumentó desde 39,4 ± 5% en los ratones C57 IM a 66,8 ± 5% en Gal-3 KO (P= 0,002). El infiltrado de macrófagos y la fibrosis en el área de IM se redujeron en los animales Gal-3 KO IM (P&lt; 0,001 C57 IM vs Gal-3 KO IM) mientras que la concentración de IL-6 en la pared libre del VI fue similar entre grupos (P=NS). En conclusión, la deleción de Gal-3 es un factor importante para la cinética del proceso reparativo regulando el infiltrado de macrófagos, el grado de fibrosis de la zona infartada, como así también en la evolución temprana del remodelamiento post-IM.

Background: Galectin-3 (Gal-3) is a lectin that regulates the immune response. However, its role in remodeling and ventricular function after myocardial infarction (MI) is unknown. Objective: The purpose of this study was to analyze whether Gal-3 deficit impairs remodeling and ventricular function after MI in mice. Methods: Male Gal-3 KO mice and their respective C57 controls underwent anterior descending coronary artery ligation or sham operation. Animals were then divided into four experimental groups: 1) C57 sham; 2) Gal-3 KO sham; 3) C57 MI and 4) Gal-3 KO MI. Seven days after surgery, an echocardiography was performed followed by euthanasia. Heart samples were collected to measure MI size and fibrosis using Masson’s trichrome and picrosirius red, respectively, and assess macrophage infiltration and IL-6 expression. Results: Left ventricular diameters were significantly increased in the C57 MI group compared with sham animals and the increase was even higher in the Gal-3 KO MI group. Moreover, ejection fraction decreased to 47%±2% in C57 MI and 37%±3% in Gal-3 KO MI mice (p&lt;0.02), and infarct size increased from 39.4%±5% in C57 MI to 66.8%±5% in Gal-3 KO MI animals (p=0.002). Macrophage infiltration and fibrosis in the MI area were significantly reduced in Gal-3 KO MI mice (p&lt;0.001 C57 MI vs. Gal-3KO MI) without changes of IL-6 concentration in the left ventricular free wall (p=ns). Conclusions: Gal-3 gene deletion is an important factor in repair kinetics, regulating macrophage infiltration and the degree of fibrosis in the infarct area, as well as early remodeling after MI.

Metadatos destacados

Colecciones
Argentine Journal of Cardiology

Editor

Sociedad Argentina de Cardiología

Fuente

Revista Argentina de Cardiología; Vol 83, No 4 (2015); 287-292, Argentine Journal of Cardiology; Vol 83, No 4 (2015); 287-292

Citación

Wilensky, Luciana et al., “Efecto del déficit de galectina-3 sobre la remodelación ventricular posoclusión coronaria en ratones,” Archivo PPCT, consulta 2 de abril de 2026, http://archivoppct.caicyt.gov.ar/items/show/9020.

Dublin Core

Autor

Wilensky, Luciana
Martínez Naya, Nadia L.
Cassaglia, Pablo
Volberg, Verónica
Tau, Julia
Aruanno, Eugenia
Morgunowsky Michell, Isaac
Morales, Celina
González, Germán E.; Dpto. de Patologia, Fac. de Medicina, UBA
Pte. Uriburu 950, piso 2, CABA.

Fuente

Revista Argentina de Cardiología; Vol 83, No 4 (2015); 287-292
Argentine Journal of Cardiology; Vol 83, No 4 (2015); 287-292

Editor

Sociedad Argentina de Cardiología

Fecha

2015-08-25

Derechos

Los que firman al pié, certificamos que tenemos total responsabilidad por la conducción de este estudio y por el diseño y la interpretación de los datos. Nosotros escribimos el manuscrito y somos responsables por la decisión acerca del mismo. Cada uno de nosotros cumple la definición de autor como se afirma en el Comité Internacional de Editores de Revistas Médicas (International Committee of Medical Journal Editors, ver www.icmje.org). Nosotros hemos visto y aprobado el manuscrito final. Ni el artículo, ni ninguna parte esencial del mismo, incluido las tablas y las figuras, será publicado o admitido para arbitrar a otra parte antes de aparecer en la Revista.También notificamos haber leído la sección “conflicto de intereses”, y revelaríamos cualquiera que existiera. Dejamos constancia que si nuestro artículo se publicara en la RAC, cederíamos los derechos (copyright) a la Revista.Los documentos publicados en esta revista están bajo la licencia Creative Commons Atribución-NoComercial-Compartir-Igual 2.5 Argentina.
Those signing below certify that we have full responsibility for the conduction of this study and for the design and interpretation of the information. We wrote the manuscript and are responsible for its decision. Each of us fulfills the definition of authorship as stated by the International Committee of Medical Journal Editors ( www.icmje.org). We have signed and approved the final manuscript. Neither the manuscript, nor any essential part thereof, including tables and figures, will be published or accepted for refereeing elsewhere before being published in the Journal. We have also read the "Conflict of Interest" section and would disclose any existing. We state that if our manuscript is published in the RAC, we shall transfer the copyright to the Journal.

Formato

Idioma

spa
eng

Tipo

info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion