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65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f trailer <]>> startxref 116 %%EOF Papel de la tiorredoxina-1 en el atontamiento cardíaco en ratones transgénicos - Archivo PPCT

Papel de la tiorredoxina-1 en el atontamiento cardíaco en ratones transgénicos;
Role of Thioredoxin-1 on Myocardial Stunning in Transgenic Mice

Creators:Mazo, Tamara; 1Instituto de Fisiopatología Cardiovascular (INFICA) – Dpto. de Patología, Facultad de Medicina, UBA, Pérez, Virginia, Gómez, Anabella, Llamosas, Clara, Váldez, Laura, Zaobornyj, Tamara, Nicolosi, Liliana, Rubio, María C., D'Annunzio, Verónica, Gelpi, Ricardo J.
2015-11-30

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Descripción

La disfunción ventricular post-isquémica (miocardio atontado), involucra un aumento del estrés oxidativo. En este sentido, la célula cuenta con mecanismos de defensa, como tioredoxina-1 que es un antioxidante que protege al miocardio de la injuria por isquemia/reperfusión, reduciendo el tamaño de infarto. De esta manera, el objetivo del presente trabajo fue evaluar el comportamiento de la función ventricular sistólica y diastólica, particularmente estudiando la rigidez miocárdica y la relajación isovolúmica en el miocardio atontado en diferentes ratones transgénicos. Se utilizaron corazones de ratones que sobreexpresan tioredoxina-1 y de ratones transgénicos que sobreexpresan tioredoxina-1 mutada en su sitio activo (dominante negativo), comparados con los de ratones no transgénicos, los cuales fueron sometidos a 15 minutos de isquemia global y 30 minutos de reperfusión utilizando la técnica de Langendorff. Se evaluó la función ventricular sistólica, diastólica y se calculó el t63, como índice de relajación isovolúmica. Las mediciones a los 30 minutos de reperfusión mostraron una mejoría significativa del estado contráctil en los ratones tioredoxina-1 (57.4±4.9 mmHg, p≤0.05 versus no transgénicos) y también en la rigidez (11.8±2.9 mmHg; p≤0.05 versus no transgénicos). Por otra parte, en los ratones dominante negativos se observó un aumento de la rigidez (37.7±5.5 mmHg, p≤0.05 versus no transgénicos) y un enlentecimiento de la relajación a los 30 minutos de la reperfusión (78.2±9.8 mseg, p&lt;0.05 versus no transgénicos). Este trabajo evidencia el rol protector de tioredoxina-1 en el miocardio atontado y su importancia fisiopatológica, en ratones que sobreexpresan este antioxidante.

Metadatos destacados

Colecciones
Argentine Journal of Cardiology

Editor

Sociedad Argentina de Cardiología

Fuente

Revista Argentina de Cardiología; Vol 83, No 5 (2015); 394-399, Argentine Journal of Cardiology; Vol 83, No 5 (2015); 394-399

Citación

Mazo, Tamara; 1Instituto de Fisiopatología Cardiovascular (INFICA) – Dpto. de Patología, Facultad de Medicina, UBA et al., “Papel de la tiorredoxina-1 en el atontamiento cardíaco en ratones transgénicos,” Archivo PPCT, consulta 2 de abril de 2026, http://archivoppct.caicyt.gov.ar/items/show/9025.

Dublin Core

Autor

Mazo, Tamara; 1Instituto de Fisiopatología Cardiovascular (INFICA) – Dpto. de Patología, Facultad de Medicina, UBA
Pérez, Virginia
Gómez, Anabella
Llamosas, Clara
Váldez, Laura
Zaobornyj, Tamara
Nicolosi, Liliana
Rubio, María C.
D'Annunzio, Verónica
Gelpi, Ricardo J.

Fuente

Revista Argentina de Cardiología; Vol 83, No 5 (2015); 394-399
Argentine Journal of Cardiology; Vol 83, No 5 (2015); 394-399

Editor

Sociedad Argentina de Cardiología

Fecha

2015-11-30

Derechos

Los que firman al pié, certificamos que tenemos total responsabilidad por la conducción de este estudio y por el diseño y la interpretación de los datos. Nosotros escribimos el manuscrito y somos responsables por la decisión acerca del mismo. Cada uno de nosotros cumple la definición de autor como se afirma en el Comité Internacional de Editores de Revistas Médicas (International Committee of Medical Journal Editors, ver www.icmje.org). Nosotros hemos visto y aprobado el manuscrito final. Ni el artículo, ni ninguna parte esencial del mismo, incluido las tablas y las figuras, será publicado o admitido para arbitrar a otra parte antes de aparecer en la Revista.También notificamos haber leído la sección “conflicto de intereses”, y revelaríamos cualquiera que existiera. Dejamos constancia que si nuestro artículo se publicara en la RAC, cederíamos los derechos (copyright) a la Revista.Los documentos publicados en esta revista están bajo la licencia Creative Commons Atribución-NoComercial-Compartir-Igual 2.5 Argentina.
Those signing below certify that we have full responsibility for the conduction of this study and for the design and interpretation of the information. We wrote the manuscript and are responsible for its decision. Each of us fulfills the definition of authorship as stated by the International Committee of Medical Journal Editors ( www.icmje.org). We have signed and approved the final manuscript. Neither the manuscript, nor any essential part thereof, including tables and figures, will be published or accepted for refereeing elsewhere before being published in the Journal. We have also read the "Conflict of Interest" section and would disclose any existing. We state that if our manuscript is published in the RAC, we shall transfer the copyright to the Journal.

Formato

Idioma

eng
spa

Tipo

info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion