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miocárdica a distancia - Archivo PPCT

Mecanismos de protección miocárdica a distancia;
Remote Mechanisms of Myocardial Protection

Creators:Goyeneche, María A., Donato, Martín, Páez, DIAMELA T., Garcés, Mariana, Marchini, Timoteo, Pérez, Virginia, Grinspun, Martín, del Mauro, Julieta, Höcht, Christian, Evelson, Pablo, Gelpi, Ricardo J.
2016-06-28

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Descripción

Introducción: Se ha propuesto que el precondicionamiento isquémico remoto (PCr) reduce el tamaño del infarto a través de la activaciónde una vía neuronal parasimpática. Sin embargo, los mecanismos intracelulares responsables de esta protección no se conocencompletamente.Objetivo: Describir algunas de las señales intracelulares activadas a nivel cardíaco por el PCr antes de la isquemia miocárdica y queparticipan en la protección.Material y métodos: Corazones aislados de ratas fueron sometidos a 30 minutos de isquemia global, seguidos de 120 minutos dereperfusión (I/R). En un segundo grupo, antes del aislamiento del corazón se realizó un protocolo de PCr (tres ciclos de isquemia/reperfusión en la arteria femoral izquierda); una vez finalizado, se repitió el protocolo del grupo I/R. Adicionalmente, se estudiaroncuatro grupos experimentales, en los que antes del PCr se realizó una vagotomía cervical bilateral [SV (sección vagal)] o se administróatropina (bloqueante de los receptores muscarínicos), L-NAME (inhibidor de la síntesis de NO) y 5-HD (bloqueante de los canalesmK+ATP), respectivamente. Se midieron el tamaño del infarto y la fosforilación de la eNOS en los grupos I/R, PCr y SV. Por otro lado,se midió la producción mitocondrial de H2O2.Resultados: El PCr redujo significativamente el tamaño del infarto y este efecto fue abolido por la SV y con los tratamientos conatropina, L-NAME y 5-HD. Además, el PCr incrementó la fosforilación de la eNOS y este efecto fue abolido por la SV. Finalmente, elPCr produjo un aumento de la producción de H2O2 mitocondrial, hecho que también fue abolido con la SV.Conclusiones: El PCr activa una vía muscarínica vagal, que involucra la fosforilación de la eNOS, la apertura de los canales mK+ATPde la mitocondria y un aumento de la producción de H2O2 mitocondrial. 

Background: Remote ischemic preconditioning (rIPC) has been suggested to reduce infarct size through the activation of a parasympatheticneural pathway. However, the intracellular mechanisms responsible for this protection remain unclear.Objective: The aim of this study was to describe some of the intracellular protective signals activated at the cardiac level by rIPCprior to myocardial ischemia.Methods: Isolated rat hearts were subjected to 30 minutes of global ischemia and 120 minutes of reperfusion (I/R). In a secondgroup, before the isolation of the heart, a rIPC protocol (three cycles of left femoral artery ischemia/reperfusion) was performed,followed by the I/R protocol. Additionally, four experimental groups were studied, in which prior to the rIPC protocol a bilateralcervical vagotomy [VS (vagal section)] was performed or atropine (muscarinic receptor blocker), L-NAME (NO synthesis inhibitor),and 5-HD (mK+ATP channel blocker) was administered, respectively. Infarct size and eNOS phosphorylation were measured in I/R,rIPC, and VS groups. Finally, mitochondrial H2O2 production was assessed.Results: Remote ischemic preconditioning significantly decreased infarct size and this effect was abolished by VS and atropine,L-NAME, and 5-HD treatments. Furthermore, rIPC increased eNOS phosphorylation and this effect was abolished by VS. Finally,rIPC increased the mitochondrial H2O2 production, and this effect was also abolished by VS.Conclusions: Remote ischemic preconditioning activates a muscarinic vagal pathway involving eNOS phosphorylation, opening ofmitochondrial mK+ATP channels, and the production of mitochondrial H2O2.

Metadatos destacados

Colecciones
Argentine Journal of Cardiology

Editor

Sociedad Argentina de Cardiología

Fuente

Revista Argentina de Cardiología; Vol 84, No 3 (2016); 202-207, Argentine Journal of Cardiology; Vol 84, No 3 (2016); 202-207

Citación

Goyeneche, María A. et al., “Mecanismos de protección miocárdica a distancia,” Archivo PPCT, consulta 2 de abril de 2026, http://archivoppct.caicyt.gov.ar/items/show/9199.

Dublin Core

Autor

Goyeneche, María A.
Donato, Martín
Páez, DIAMELA T.
Garcés, Mariana
Marchini, Timoteo
Pérez, Virginia
Grinspun, Martín
del Mauro, Julieta
Höcht, Christian
Evelson, Pablo
Gelpi, Ricardo J.

Fuente

Revista Argentina de Cardiología; Vol 84, No 3 (2016); 202-207
Argentine Journal of Cardiology; Vol 84, No 3 (2016); 202-207

Editor

Sociedad Argentina de Cardiología

Fecha

2016-06-28

Derechos

Los que firman al pié, certificamos que tenemos total responsabilidad por la conducción de este estudio y por el diseño y la interpretación de los datos. Nosotros escribimos el manuscrito y somos responsables por la decisión acerca del mismo. Cada uno de nosotros cumple la definición de autor como se afirma en el Comité Internacional de Editores de Revistas Médicas (International Committee of Medical Journal Editors, ver www.icmje.org). Nosotros hemos visto y aprobado el manuscrito final. Ni el artículo, ni ninguna parte esencial del mismo, incluido las tablas y las figuras, será publicado o admitido para arbitrar a otra parte antes de aparecer en la Revista.También notificamos haber leído la sección “conflicto de intereses”, y revelaríamos cualquiera que existiera. Dejamos constancia que si nuestro artículo se publicara en la RAC, cederíamos los derechos (copyright) a la Revista.Los documentos publicados en esta revista están bajo la licencia Creative Commons Atribución-NoComercial-Compartir-Igual 2.5 Argentina.
Those signing below certify that we have full responsibility for the conduction of this study and for the design and interpretation of the information. We wrote the manuscript and are responsible for its decision. Each of us fulfills the definition of authorship as stated by the International Committee of Medical Journal Editors ( www.icmje.org). We have signed and approved the final manuscript. Neither the manuscript, nor any essential part thereof, including tables and figures, will be published or accepted for refereeing elsewhere before being published in the Journal. We have also read the "Conflict of Interest" section and would disclose any existing. We state that if our manuscript is published in the RAC, we shall transfer the copyright to the Journal.

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Idioma

eng
spa

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info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion