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ventrículoarterial en la estenosis aórtica grave: relación con los síntomas y con insuficiencia cardíaca - Archivo PPCT

Cupla ventrículoarterial en la estenosis aórtica grave: relación con los síntomas y con insuficiencia cardíaca;
Ventricular-Arterial Coupling in Severe Aortic Stenosis: Relationship with Symptoms and Heart Failure

Creators:Migliore, Ricardo A., Adaniya, María E., Barranco, Miguel, Dorsch, Jeremías, Miramont, Guillermo, González, Silvia, Tamagusuki, Horacio
2016-09-22

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Descripción

Introducción: La función del ventrículo izquierdo (VI) está determinada por el acoplamiento entre la elastancia arterial efectiva (Ea) y la elastancia de fin de sístole del VI (Efs). En la estenosis aórtica (EAo) las características de la vasculatura pueden influir sobre la función del VI especialmente en pacientes con síntomas o insuficiencia cardíaca (IC). Objetivo: Evaluar la cupla ventrículo-arterial mediante la relación Ea /Efs en pacientes con estenosis aórtica grave y su relación con los síntoma e IC. Material y métodos: Se incluyeron 136 pacientes, edad promedio 69 ± 11 años, portadores de EAo grave (área valvular aórtica (AVA) &lt; 1 cm2). Ea y Efs fueron estimadas en forma no invasiva. Los pacientes fueron divididos en tres grupos: IC (n = 48), sintomáticos (n = 45) y asintomáticos (n = 43). Resultados: La Ea se observó incrementada en los pacientes con IC mientras que la Efs estuvo significativamente disminuida en los pacientes sintomáticos y con IC con respecto a los asintomáticos. Ea /Efs fue significativamente mayor en los pacientes sintomáticos y con IC comparados con los pacientes asintomáticos (1.5 ± 1.3 y 0.81 ± 0.49 vs 0.61 ± 0.37, &lt;0.01). No hubo diferencias en el AVA entre los grupos. Conclusiones: Efs/ Ea estuvo reducida en pacientes con síntomas o IC debido al incremento de Ea y la disminución de Efs. La aparición de síntomas o IC en la EAo grave parece estar relacionada con las características de la vasculatura, independientemente de la gravedad de la estenosis valvular.

Background: Left ventricular function is determined by ventricular-arterial coupling via effective arterial elastance (Ea) and leftventricular end-systolic elastance (Ees). In aortic stenosis, the characteristics of the vascular system may influence left ventricularfunction, particularly in patients with symptoms or heart failure.Objective: The aim of the present study was to evaluate ventricular-arterial coupling using the Ea/Ees ratio in patients with severeaortic stenosis and its relationship with symptoms and heart failure.Methods: The cohort consisted of 136 patients aged 69±11 years, with severe aortic stenosis (aortic valve area &lt;1 cm2). Ea and Eeswere estimated noninvasively. Patients were divided into three groups: heart failure (n=48), symptomatic (n=45) and asymptomatic(n=43).Results: Ea was increased in patients with heart failure while Ees was significantly reduced in patients with symptoms and withheart failure compared with asymptomatic ones. The Ea/Ees ratio was significantly higher in symptomatic and heart failure patientscompared with asymptomatic patients (1.5±1.3 and 0.81±0.49 vs. 0.61±0.37; p&lt;0.01). There were no significant differences inaortic valve area among groups.Conclusions: The Ea/Ees ratio was increased in patients with symptoms or heart failure due to increased Ea and reduced Ees. Thedevelopment of symptoms or heart failure in severe aortic stenosis seems to be related with the characteristics of the vascular system,irrespectively of aortic stenosis severity.

Metadatos destacados

Colecciones
Argentine Journal of Cardiology

Editor

Sociedad Argentina de Cardiología

Fuente

Revista Argentina de Cardiología; Vol 84, No 4 (2016); 315-321, Argentine Journal of Cardiology; Vol 84, No 4 (2016); 315-321

Citación

Migliore, Ricardo A. et al., “Cupla ventrículoarterial en la estenosis aórtica grave: relación con los síntomas y con insuficiencia cardíaca,” Archivo PPCT, consulta 2 de abril de 2026, http://archivoppct.caicyt.gov.ar/items/show/9228.

Dublin Core

Autor

Migliore, Ricardo A.
Adaniya, María E.
Barranco, Miguel
Dorsch, Jeremías
Miramont, Guillermo
González, Silvia
Tamagusuki, Horacio

Fuente

Revista Argentina de Cardiología; Vol 84, No 4 (2016); 315-321
Argentine Journal of Cardiology; Vol 84, No 4 (2016); 315-321

Editor

Sociedad Argentina de Cardiología

Fecha

2016-09-22

Derechos

Los que firman al pié, certificamos que tenemos total responsabilidad por la conducción de este estudio y por el diseño y la interpretación de los datos. Nosotros escribimos el manuscrito y somos responsables por la decisión acerca del mismo. Cada uno de nosotros cumple la definición de autor como se afirma en el Comité Internacional de Editores de Revistas Médicas (International Committee of Medical Journal Editors, ver www.icmje.org). Nosotros hemos visto y aprobado el manuscrito final. Ni el artículo, ni ninguna parte esencial del mismo, incluido las tablas y las figuras, será publicado o admitido para arbitrar a otra parte antes de aparecer en la Revista.También notificamos haber leído la sección “conflicto de intereses”, y revelaríamos cualquiera que existiera. Dejamos constancia que si nuestro artículo se publicara en la RAC, cederíamos los derechos (copyright) a la Revista.Los documentos publicados en esta revista están bajo la licencia Creative Commons Atribución-NoComercial-Compartir-Igual 2.5 Argentina.
Those signing below certify that we have full responsibility for the conduction of this study and for the design and interpretation of the information. We wrote the manuscript and are responsible for its decision. Each of us fulfills the definition of authorship as stated by the International Committee of Medical Journal Editors ( www.icmje.org). We have signed and approved the final manuscript. Neither the manuscript, nor any essential part thereof, including tables and figures, will be published or accepted for refereeing elsewhere before being published in the Journal. We have also read the "Conflict of Interest" section and would disclose any existing. We state that if our manuscript is published in the RAC, we shall transfer the copyright to the Journal.

Formato

Idioma

spa
eng

Tipo

info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion