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Características clínicas y evolutivas del síndrome de Takotsubo en un Hospital Universitario;
Clinical Features and Outcomes of Takotsubo Syndrome at a University Hospital

Creators:Arias, Anibal, Lucas, Luciano O., Espinosa, Ezequiel, Iezzi, Sebastián, Rossi, Emiliano, San Román, Eduardo, Pizarro, Rodolfo, Belziti, César A., Cagide, Arturo M., Doval, Hernán C.
2018-06-26

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Descripción

Introducción: El síndrome de Takotsubo (ST) es una miocardiopatía reversible que tiene diversas formas de presentación. Hasta el momento no se han publicado datos de ST en nuestro medio. Material y Métodos: Desde el 2005 al 2017 se incluyeron a 115 pacientes con diagnóstico de ST primario o secundario en el Hospital Italiano de Buenos Aires. El objetivo fue evaluar las características clínicas del ST durante la internación. Resultados: La mediana de edad de la población fue de 78 años (64-84), el 90% eran mujeres, y el 22% presentó enfermedad coronaria asociada. El 57% eran ST primarios, 31% tuvieron un gatillo emocional y 44%, físico. El síndrome de presentación fue como shock: 9%, insuficiencia cardiaca 12%, “tipo SCA” 70%, ACV/embolia 5% y, arritmias, 4%. La mediana de Fey al ingreso fue del 40% (36-50) y su recuperación, desde el ingreso al alta (mediana de internación de 4 días, 3-8), fue del 20%, p &lt; 0.001. La mortalidad hospitalaria fue de 4/115 (3,48%). En el análisis univariado, las variables asociadas a mayor mortalidad fueron: shock respecto a otras formas de presentación (p = 0.0035) y ST secundario respecto al primario, p = 0.020. Además, existió una relación directa entre la mortalidad y los niveles de NT-pro-BNP máximo (p = 0.0082) y glóbulos blancos (p = 0.0101).   Asimismo, la mortalidad hospitalaria mostró una relación inversa con el hematocrito (p = 0.0084) y con las alteraciones en el ECG de ingreso; es decir, que los pacientes que fallecieron durante la internación tuvieron ECG normal al ingreso con mayor frecuencia (p &lt; 0.001). Conclusión: En este registro unicéntrico se observó que los pacientes tuvieron más comorbilidades y similar mortalidad respecto a registros internacionales.

Background: Takotsubo syndrome (TS) is a reversible cardiomyopathy with many different forms of presentations. There is no local data of TS published so far. Methods: One hundred and fifteen patients with either primary or secondary TS were retrospectively studied at Hospital Italiano de Buenos Aires from 2005 to 2017. The purpose of the study was to assess the clinical features of this population during hospitalization. Results: Median of age was 78 years (64-84); 90 % of patients were female, and 22% had associated coronary artery disease. Fiftyseven percent of cases were primary TS, 31 % experienced an emotional trigger and 44 % had a physical origin. The presentation syndrome was as follows: 9 % shock, 12 % heart failure, 70 % mimicking acute coronary syndrome, 5 % stroke/peripheral embolism and 4 % arrhythmias. Median ejection fraction at admission was 40 % (36-50) and recovery from admission to discharge [median hospital stay: 4 days (3-8)] was 20 %, p &lt;0.001. In-hospital mortality was 4/115 cases (3.48 %). In univariate analysis, shock compared with other forms of presentation (p=0.0035) and secondary TS (p=0.020) were associated with higher in-hospital mortality. There was a direct relationship between in-hospital mortality and maximum NT-pro-BNP levels (p= 0.0082) and white cell count (p=0.0101). In addition, in-hospital mortality was inversely associated with hematocrit (p=0.0084) and with ECG abnormalities at admission; i.e. patients who died during hospitalization had more frequently normal ECG at admission, (p&lt;0.001). Conclusion: Compared with international registries, this single center population had more comorbidities, but similar in-hospital mortality rates.

Metadatos destacados

Colecciones
Argentine Journal of Cardiology

Editor

Sociedad Argentina de Cardiología

Fuente

Revista Argentina de Cardiología; Vol 86, No 2 (2018); 90-95, Argentine Journal of Cardiology; Vol 86, No 2 (2018); 90-95

Citación

Arias, Anibal et al., “Características clínicas y evolutivas del síndrome de Takotsubo en un Hospital Universitario,” Archivo PPCT, consulta 2 de abril de 2026, http://archivoppct.caicyt.gov.ar/items/show/9433.

Dublin Core

Autor

Arias, Anibal
Lucas, Luciano O.
Espinosa, Ezequiel
Iezzi, Sebastián
Rossi, Emiliano
San Román, Eduardo
Pizarro, Rodolfo
Belziti, César A.
Cagide, Arturo M.
Doval, Hernán C.

Fuente

Revista Argentina de Cardiología; Vol 86, No 2 (2018); 90-95
Argentine Journal of Cardiology; Vol 86, No 2 (2018); 90-95

Editor

Sociedad Argentina de Cardiología

Fecha

2018-06-26

Derechos

Los que firman al pié, certificamos que tenemos total responsabilidad por la conducción de este estudio y por el diseño y la interpretación de los datos. Nosotros escribimos el manuscrito y somos responsables por la decisión acerca del mismo. Cada uno de nosotros cumple la definición de autor como se afirma en el Comité Internacional de Editores de Revistas Médicas (International Committee of Medical Journal Editors, ver www.icmje.org). Nosotros hemos visto y aprobado el manuscrito final. Ni el artículo, ni ninguna parte esencial del mismo, incluido las tablas y las figuras, será publicado o admitido para arbitrar a otra parte antes de aparecer en la Revista.También notificamos haber leído la sección “conflicto de intereses”, y revelaríamos cualquiera que existiera. Dejamos constancia que si nuestro artículo se publicara en la RAC, cederíamos los derechos (copyright) a la Revista.Los documentos publicados en esta revista están bajo la licencia Creative Commons Atribución-NoComercial-Compartir-Igual 2.5 Argentina.
Those signing below certify that we have full responsibility for the conduction of this study and for the design and interpretation of the information. We wrote the manuscript and are responsible for its decision. Each of us fulfills the definition of authorship as stated by the International Committee of Medical Journal Editors ( www.icmje.org). We have signed and approved the final manuscript. Neither the manuscript, nor any essential part thereof, including tables and figures, will be published or accepted for refereeing elsewhere before being published in the Journal. We have also read the "Conflict of Interest" section and would disclose any existing. We state that if our manuscript is published in the RAC, we shall transfer the copyright to the Journal.

Formato

Idioma

spa
eng

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info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion