Losartán y metformina previenen alteraciones en el tejido adiposo perivascular y en la liberación de prostanoides del lecho vascular mesentérico producidas por una dieta alta en grasa y sobrecarga de fructosa en la rata;
Losartan and Metformin Prevent Abnormalities in Perivascular Adipose Tissue and in Mesenteric Vascular Bed Prostanoid Release Induced by High-fat High-fructose Diet in Rats

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Objective: The aim of this study was to analyze the effects of losartan (30 mg/kg/day) and metformin (500 mg/kg/day) on the adiposityindex and the mesenteric vascular bed prostanoid release, and their relationship with systolic blood pressure in a metabolicsyndrome model induced by high-fat high fructose-diet in male Sprague-Dawley rats for 9 weeks..Methods: Mesenteric vascular beds were extracted and incubated and prostanoids were measured by high-performance liquid chromatography.Systolic blood pressure was measured by an indirect method.Results: High-fat high-fructose diet produced a significant increase in systolic blood pressure and mesenteric vascular bed adiposityindex and in the release of vasoconstrictor prostanoids as thromboxane B2 and prostaglandin F2α and of prostaglandin E2, a markerof inflammation. The PGI2/TXA2 ratio was significantly reduced. The administration of losartan and metformin prevented all thesechanges.Conclusion: Both drugs have beneficial effects on mesenteric perivascular adipose tissue by improving endothelial dysfunction inducedby an imbalance of vasoactive substances.