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Tratamiento antiagregante guiado por pruebas de función plaquetaria en pacientes sometidos a angioplastia coronaria exitosa.;
Antiplatelet Therapy Guided by Platelet Function Testing after Successful Percutaneous Coronary Intervention

Creators:Candiello, Alfonsina; Servicio de Cardiología Intervencionista y Terapéuticas Endovasculares.
Instituto Cardiovascular de Buenos Aires, Cura, Fernando; Servicio de Cardiología Intervencionista y Terapéuticas Endovasculares.
Instituto Cardiovascular de Buenos Aires, Trivi, Marcelo; Servicio de Cardiología Clínica.
Instituto Cardiovascular de Buenos Aires, Padilla, Lucio; Servicio de Cardiología Intervencionista y Terapéuticas Endovasculares.
Instituto Cardiovascular de Buenos Aires, Albertal, Mariano; Departamento de Investigación.
Instituto Cardiovascular de Buenos Aires, Nau, Gerardo; Servicio de Cardiología Intervencionista y Terapéuticas Endovasculares.
Instituto Cardiovascular de Buenos Aires, Aris Cancela, Maria Esther; Servicio de Hematología.
Instituto Cardiovascular de Buenos Aires, Peralta, Sebastian; Servicio de Cardiología Intervencionista y Terapéuticas Endovasculares.
Instituto Cardiovascular de Buenos Aires, Torrent, Fabricio; Servicio de Cardiología Intervencionista y Terapéuticas Endovasculares.
Instituto Cardiovascular de Buenos Aires, Belardi, Jorge; Servicio de Cardiología Intervencionista y Terapéuticas Endovasculares.
Instituto Cardiovascular de Buenos Aires
2012-10-01

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Descripción

El tratamiento antiagregante con aspirina y clopidogrel constituye un tratamiento esencial para la prevención de eventos isquémicos en pacientes sometidos a Angioplastia Coronaria(ATC). Sin embargo, existe alta variabilidad en la respuesta al clopidogrel, condicionando la falla en su efecto terapéutico, manifestado como hiperreactividad plaquetaria residual(HPR). Objetivos.1)Evaluar la respuesta antiagregante en pacientes sometidos a ATC exitosa pretratados con clopidogrel o prasugrel; 2)evaluar la respuesta a una carga de prasugrel en pacientes con HPR bajo tratamiento con clopidogrel.Materiales y Métodos.Se incluyeron 83 pacientes sometidos a ATC pretratados con:aspirina más clopidogrel(carga de 600mg o 75 mg/día &gt;7 días;n=42) o prasugrel(60mg ó 10 mg/día &gt;7 días,n=41). La función plaquetaria fue evaluada 12-24hs. post-ATC con el método VerifyNow®. Se definió HPR a la presencia de ≥ 230 unidades de reactividad plaquetaria(URP). Los pacientes con HPR recibieron una carga de prasugrel 60 mg reevaluándose la función plaquetaria a las 2 hs.Resultados.No hubo diferencias significativas en las características basales. A 12-24hs post-ATC el grupo prasugrel presentó menor URP comparado con el grupo clopidogrel(mediana 49(9-78) vs. 160(82-224), p&lt;0.001). Un 24% de los pacientes del grupo clopidogrel y ninguno del grupo prasugrel presentó HPR, p&lt;0.001. Todos los pacientes con HPR bajo tratamiento con clopidogrel lograron corregirla luego de la carga de prasugrel.Conclusión.En pacientes sometidos a ATC exitosa, el tratamiento con prasugrel logró una mayor inhibición de la agregación plaquetaria (IAP) comparada con la administración de clopidogrel. Aquellos pacientes con HPR bajo tratamiento con clopidogrel lograron alcanzar una óptima IAP con la administración adicional de prasugrel.

Background Dual antiplatelet therapy with aspirin and clopidogrel is an essential treatment to prevent ischemic events in patients undergoing percutaneous coronary intervention (PCI). However, a significant interindividual variability exists in response to clopidogrel treatment, which is responsible for failure in the therapeutic effect and in the development of high residual platelet reactivity (HRPR). Prasugrel could reduce this prothrombotic state. Objectives To evaluate: 1) the antiaggregant response in clopidogrel or prasugrel pretreated patients undergoing successful PCI, and 2) the response to prasugrel loading in patients with low residual platelet reactivity on clopidogrel therapy. Material and Methods Eighty three patients were prospectively included in the study. They underwent successful PCI under dual antiplatelet therapy: aspirin plus clopidogrel (600 mg loading dose or a maintenance dose of 75 mg for more than 7 days; n=42) or prasugrel (60 mg loading dose or a maintenance dose of 10 mg for more than 7 days; n=41). The selection of thienopyridine was left at the discretion of the treating physician. Patients with high hemorrhagic risk were excluded. Platelet function was tested 12-24 hours after PCI with the VerifyNowTMP2Y12 Assay. High residual platelet reactivity (HRPR) was defined as P2Y12-reaction units (PRU) ³ 230. In case of HRPR, patients received a loading dose of prasugrel 60 mg and platelet function was reassessed 2 hours later. Results Baseline characteristics did not differ in patients who initially received clopidogrel or prasugrel. At 12-24 hours post PCI, patients treated with prasugrel presented significantly less PRU compared with the clopidogrel cohort (median 49 (9-78) vs. 160 (82-224); p &lt; 0.001). HRPR was observed in 24% of patients in the clopidogrel group and in no patients in the prasugrel cohort (p &lt; 0.001). All patients with HRPR on clopidogrel treatment corrected this value after the loading dose of prasugrel. Conclusions After successful PCI, prasugrel administration achieved greater platelet inhibition compared to clopidogrel. Moreover, in patients with high-on treatment platelet reactivity with clopidogrel, optimal platelet inhibition was accomplished by additional prasugrel administration.

Metadatos destacados

Colecciones
Argentine Journal of Cardiology

Editor

Sociedad Argentina de Cardiología

Fuente

Revista Argentina de Cardiología; Vol 80, No 5 (2012); 352-356, Argentine Journal of Cardiology; Vol 80, No 5 (2012); 352-356

Citación

Candiello, Alfonsina; Servicio de Cardiología Intervencionista y Terapéuticas Endovasculares. Instituto Cardiovascular de Buenos Aires et al., “Tratamiento antiagregante guiado por pruebas de función plaquetaria en pacientes sometidos a angioplastia coronaria exitosa.,” Archivo PPCT, consulta 2 de abril de 2026, http://archivoppct.caicyt.gov.ar/items/show/8058.

Dublin Core

Materia

Autor

Candiello, Alfonsina; Servicio de Cardiología Intervencionista y Terapéuticas Endovasculares.
Instituto Cardiovascular de Buenos Aires
Cura, Fernando; Servicio de Cardiología Intervencionista y Terapéuticas Endovasculares.
Instituto Cardiovascular de Buenos Aires
Trivi, Marcelo; Servicio de Cardiología Clínica.
Instituto Cardiovascular de Buenos Aires
Padilla, Lucio; Servicio de Cardiología Intervencionista y Terapéuticas Endovasculares.
Instituto Cardiovascular de Buenos Aires
Albertal, Mariano; Departamento de Investigación.
Instituto Cardiovascular de Buenos Aires
Nau, Gerardo; Servicio de Cardiología Intervencionista y Terapéuticas Endovasculares.
Instituto Cardiovascular de Buenos Aires
Aris Cancela, Maria Esther; Servicio de Hematología.
Instituto Cardiovascular de Buenos Aires
Peralta, Sebastian; Servicio de Cardiología Intervencionista y Terapéuticas Endovasculares.
Instituto Cardiovascular de Buenos Aires
Torrent, Fabricio; Servicio de Cardiología Intervencionista y Terapéuticas Endovasculares.
Instituto Cardiovascular de Buenos Aires
Belardi, Jorge; Servicio de Cardiología Intervencionista y Terapéuticas Endovasculares.
Instituto Cardiovascular de Buenos Aires

Fuente

Revista Argentina de Cardiología; Vol 80, No 5 (2012); 352-356
Argentine Journal of Cardiology; Vol 80, No 5 (2012); 352-356

Editor

Sociedad Argentina de Cardiología

Fecha

2012-10-01

Derechos

Los que firman al pié, certificamos que tenemos total responsabilidad por la conducción de este estudio y por el diseño y la interpretación de los datos. Nosotros escribimos el manuscrito y somos responsables por la decisión acerca del mismo. Cada uno de nosotros cumple la definición de autor como se afirma en el Comité Internacional de Editores de Revistas Médicas (International Committee of Medical Journal Editors, ver www.icmje.org). Nosotros hemos visto y aprobado el manuscrito final. Ni el artículo, ni ninguna parte esencial del mismo, incluido las tablas y las figuras, será publicado o admitido para arbitrar a otra parte antes de aparecer en la Revista.También notificamos haber leído la sección “conflicto de intereses”, y revelaríamos cualquiera que existiera. Dejamos constancia que si nuestro artículo se publicara en la RAC, cederíamos los derechos (copyright) a la Revista.Los documentos publicados en esta revista están bajo la licencia Creative Commons Atribución-NoComercial-Compartir-Igual 2.5 Argentina.
Those signing below certify that we have full responsibility for the conduction of this study and for the design and interpretation of the information. We wrote the manuscript and are responsible for its decision. Each of us fulfills the definition of authorship as stated by the International Committee of Medical Journal Editors ( www.icmje.org). We have signed and approved the final manuscript. Neither the manuscript, nor any essential part thereof, including tables and figures, will be published or accepted for refereeing elsewhere before being published in the Journal. We have also read the "Conflict of Interest" section and would disclose any existing. We state that if our manuscript is published in the RAC, we shall transfer the copyright to the Journal.

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spa
eng

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info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion