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Etiology influence in mortality on Heart Failure with Preserved Systolic Function on a high prevalence Chagas heart disease population.;
Influencia de la etiología sobre la mortalidad en la insuficiencia cardíaca con función sistólica preservada en una población con alta prevalencia de cardiopatía chagásica

Creators:de Andrade, Gustavo Maltez, Borges Dos Reis, Francisco
2013-07-25

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Descripción

Background: Heart Failure with Preserved Systolic Function is a clinical syndrome that has the same signs and symptoms of classic heart failure. Aim: To compare the clinical features and evolution of Heart Failure (HF) in patients with systolic dysfunction and preserved systolic function (PSF) on a high prevalence Chagas heart disease population. Methods: We prospectively evaluated patients with clinical diagnosis of HF admitted at a reference clinic in Salvador-BA (Brazil). PSF was considered as heart failure with left ventricle ejection fraction (LVEF) greater than 45% analyzed by echocardiography. One year follow-up was obtained through phone contact or personal interview at the cardiac failure clinic. Results: During a 16 months period of time, 383 patients were included, 52.5% were male and mean age was 54.2 years. PSF was observed in 138 patients (36%). The main etiology for both types of HF was Chagas disease (45.3% in systolic dysfunction and 44.2% in PSF). One-year follow-up was obtained in 358 patients (93.5%). Patients with Chagas disease and PSF had a lower mortality rate when compared with patients with systolic dysfunction (10% vs. 23.6%; p=0,039). In patients without Chagas disease and PSF mortality was similar to those with systolic dysfunction (10.4% vs. 15.8%; p=0,307). Conclusions: PSF was commonly found in our population. Chagas disease is the main etiology of HF regardless of LVEF. Patients with Chagas disease and PSF have a better prognosis than those with systolic dysfunction, probably because the formers have initial cardiac impairment.

RESUMENIntroducciónLa insuficiencia cardíaca con función sistólica preservada es un síndrome clínico con los mismossignos y síntomas de la insuficiencia cardíaca clásica. La enfermedad de Chagas es una causaimportante de insuficiencia cardíaca en América Latina, que se asocia con miocardiopatíadilatada y deterioro progresivo de la función sistólica. No existen estudios previos que hayanevaluado pacientes con insuficiencia cardíaca y función sistólica preservada de una zonaendémica en la cual la enfermedad de Chagas es la causa principal de insuficiencia cardíaca.ObjetivoComparar las características clínicas y la evolución de la insuficiencia cardíaca en pacientescon disfunción sistólica y con función sistólica preservada en una población con alta prevalenciade enfermedad de Chagas.Material y métodosSe realizó una evaluación prospectiva de los pacientes con diagnóstico clínico de insuficienciacardíaca que ingresaron a un centro de referencia en Salvador, Bahía (Brasil). Se considerófunción sistólica preservada a una fracción de eyección del ventrículo izquierdo mayor del 45%por ecocardiograma. Se realizó seguimiento al año a través de contacto telefónico o entrevistapersonal en el consultorio de insuficiencia cardíaca.ResultadosSe incluyeron 383 pacientes durante un período de 16 meses; el 52,5% eran hombres y laedad media fue de 54,2 años. La función sistólica estuvo preservada en 138 pacientes (36%).La enfermedad de Chagas fue la principal etiología de ambos tipos de insuficiencia cardíaca(45,3% con disfunción sistólica y 44,2% con función sistólica preservada). El 93,5% (358) delos pacientes completaron un año de seguimiento. Los pacientes con enfermedad de Chagasy función sistólica preservada tuvieron menor mortalidad que los pacientes con disfunciónsistólica (10% vs. 23,6%; p = 0,039). En los pacientes sin enfermedad de Chagas y funciónsistólica preservada, la mortalidad fue similar a la de aquellos con disfunción sistólica (10,4%vs. 15,8%; p = 0,307).ConclusionesLa función sistólica preservada fue muy frecuente en nuestra población. La enfermedad deChagas es la principal etiología de insuficiencia cardíaca independientemente de la fracciónde eyección del ventrículo izquierdo. Los pacientes con enfermedad de Chagas y función sistólicapreservada tienen mejor pronóstico que aquellos con disfunción sistólica, probablementeporque se encuentran en la fase inicial del compromiso cardíaco.

Metadatos destacados

Colecciones
Argentine Journal of Cardiology

Editor

Sociedad Argentina de Cardiología

Fuente

Revista Argentina de Cardiología; Vol 81, No 3 (2013); 246-250, Argentine Journal of Cardiology; Vol 81, No 3 (2013); 246-250

Citación

de Andrade, Gustavo Maltez y Borges Dos Reis, Francisco, “Etiology influence in mortality on Heart Failure with Preserved Systolic Function on a high prevalence Chagas heart disease population.,” Archivo PPCT, consulta 2 de abril de 2026, http://archivoppct.caicyt.gov.ar/items/show/8123.

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Materia

Autor

de Andrade, Gustavo Maltez
Borges Dos Reis, Francisco

Fuente

Revista Argentina de Cardiología; Vol 81, No 3 (2013); 246-250
Argentine Journal of Cardiology; Vol 81, No 3 (2013); 246-250

Editor

Sociedad Argentina de Cardiología

Fecha

2013-07-25

Derechos

Los que firman al pié, certificamos que tenemos total responsabilidad por la conducción de este estudio y por el diseño y la interpretación de los datos. Nosotros escribimos el manuscrito y somos responsables por la decisión acerca del mismo. Cada uno de nosotros cumple la definición de autor como se afirma en el Comité Internacional de Editores de Revistas Médicas (International Committee of Medical Journal Editors, ver www.icmje.org). Nosotros hemos visto y aprobado el manuscrito final. Ni el artículo, ni ninguna parte esencial del mismo, incluido las tablas y las figuras, será publicado o admitido para arbitrar a otra parte antes de aparecer en la Revista.También notificamos haber leído la sección “conflicto de intereses”, y revelaríamos cualquiera que existiera. Dejamos constancia que si nuestro artículo se publicara en la RAC, cederíamos los derechos (copyright) a la Revista.Los documentos publicados en esta revista están bajo la licencia Creative Commons Atribución-NoComercial-Compartir-Igual 2.5 Argentina.
Those signing below certify that we have full responsibility for the conduction of this study and for the design and interpretation of the information. We wrote the manuscript and are responsible for its decision. Each of us fulfills the definition of authorship as stated by the International Committee of Medical Journal Editors ( www.icmje.org). We have signed and approved the final manuscript. Neither the manuscript, nor any essential part thereof, including tables and figures, will be published or accepted for refereeing elsewhere before being published in the Journal. We have also read the "Conflict of Interest" section and would disclose any existing. We state that if our manuscript is published in the RAC, we shall transfer the copyright to the Journal.

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eng

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info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion