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65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f 0000000000 65535 f trailer <<5F7222D19743CF46BB4A5D603929FF03>]>> startxref 116 %%EOF La tiorredoxina-1 no atenúa la disfunción ventricular postisquémica a pesar de disminuir el tamaño del infarto - Archivo PPCT

La tiorredoxina-1 no atenúa la disfunción ventricular postisquémica a pesar de disminuir el tamaño del infarto;
Thioredoxin-1 Reduces Infarct Size But Does Not Improve Postischemic Ventricular Dysfunction

Creators:Pérez, Virginia, D´annunzio, Verónica, Labonia, Clara, Rey Deutsch, Ana, Gelpi, Ricardo J.
2013-07-25

Colaborador:

  • Agencia Nacional de Promoción Científica y Tecnológica (PICT 08/PICT0258) y Universidad de Buenos Aires (UBACyT 20020110100159).

Materia:

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Descripción

La tioredoxina-1 es un potente antioxidante endógeno que participa en la protección miocárdica frente a la injuria por isquemia/reperfusión. Sin embargo no se ha estudiado si esta protección se mantiene en la edad media de la vida, y si se produce una disociación entre el efecto sobre la función ventricular y el infarto de miocardio. De esta manera el objetivo principal de este trabajo fue evaluar el tamaño de infarto y la función ventricular en ratones transgénicos jóvenes y de edad media que sobreexpresan tioredoxina-1, comparándolos con sus respectivos controles no transgénicos. Para ello se utilizaron corazones aislados de ratones que fueron sometidos a una isquemia global de 30min. seguidos por 120min. de reperfusión según la técnica de Langendorff. Se realizaron 4 grupos experimentales: no transgénico jóvenes; no transgénico edad media; tioredoxina-1 jóvenes y tioredoxina-1 edad media. Se evaluó la función del ventrículo izquierdo y también se midió el tamaño de infarto (trifenil tetrazolio). La función ventricular no mostró cambios significativos entre los grupos estudiados. Sin embargo, se observó una disminución del tamaño de infarto en ratones TRX-1 jóvenes (27,6±3,5% vs no transgénico jóvenes: 42,9±6,1%), en cambio, el grupo TRX-1 de edad media no presentó cambios frente al control (49,1±6,4 vs 52,6±5,2%). Los datos obtenidos sugieren que tioredoxina-1 es capaz de reducir el tamaño de infarto en los ratones jóvenes que la sobreexpresan, sin embargo no se han evidenciado cambios en la función ventricular. Además, el efecto protector del antioxidante se abole en los ratones transgénicos en edad media de la vida.

Metadatos destacados

Colecciones
Argentine Journal of Cardiology

Editor

Sociedad Argentina de Cardiología

Fuente

Revista Argentina de Cardiología; Vol 81, No 3 (2013); 219-224, Argentine Journal of Cardiology; Vol 81, No 3 (2013); 219-224

Citación

Pérez, Virginia et al., “La tiorredoxina-1 no atenúa la disfunción ventricular postisquémica a pesar de disminuir el tamaño del infarto,” Archivo PPCT, consulta 1 de abril de 2026, http://archivoppct.caicyt.gov.ar/items/show/8213.

Dublin Core

Materia

Autor

Pérez, Virginia
D´annunzio, Verónica
Labonia, Clara
Rey Deutsch, Ana
Gelpi, Ricardo J.

Fuente

Revista Argentina de Cardiología; Vol 81, No 3 (2013); 219-224
Argentine Journal of Cardiology; Vol 81, No 3 (2013); 219-224

Editor

Sociedad Argentina de Cardiología

Fecha

2013-07-25

Colaborador

Agencia Nacional de Promoción Científica y Tecnológica (PICT 08/PICT0258) y Universidad de Buenos Aires (UBACyT 20020110100159).

Derechos

Los que firman al pié, certificamos que tenemos total responsabilidad por la conducción de este estudio y por el diseño y la interpretación de los datos. Nosotros escribimos el manuscrito y somos responsables por la decisión acerca del mismo. Cada uno de nosotros cumple la definición de autor como se afirma en el Comité Internacional de Editores de Revistas Médicas (International Committee of Medical Journal Editors, ver www.icmje.org). Nosotros hemos visto y aprobado el manuscrito final. Ni el artículo, ni ninguna parte esencial del mismo, incluido las tablas y las figuras, será publicado o admitido para arbitrar a otra parte antes de aparecer en la Revista.También notificamos haber leído la sección “conflicto de intereses”, y revelaríamos cualquiera que existiera. Dejamos constancia que si nuestro artículo se publicara en la RAC, cederíamos los derechos (copyright) a la Revista.Los documentos publicados en esta revista están bajo la licencia Creative Commons Atribución-NoComercial-Compartir-Igual 2.5 Argentina.
Those signing below certify that we have full responsibility for the conduction of this study and for the design and interpretation of the information. We wrote the manuscript and are responsible for its decision. Each of us fulfills the definition of authorship as stated by the International Committee of Medical Journal Editors ( www.icmje.org). We have signed and approved the final manuscript. Neither the manuscript, nor any essential part thereof, including tables and figures, will be published or accepted for refereeing elsewhere before being published in the Journal. We have also read the "Conflict of Interest" section and would disclose any existing. We state that if our manuscript is published in the RAC, we shall transfer the copyright to the Journal.

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eng

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info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion