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VALOR DE LA ATEROSCLEROSIS SUBCLINICA EN LA DETERMINACIÓN DEL RIESGO CARDIOVASCULAR;
Significance of Subclinical Atherosclerosis in Cardiovascular Risk Assessment

Creators:Bozzo, Raul Alberto; Instituto Cardiovascular de Buenos Aires (ICBA), Rey, Ricardo; ICBA, Manente, Diego; ICBA, Rostan, Maria; ICBA, Vitagliano, Laura; ICBA, Villamil, Alberto; ICBA
2016-06-28

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Descripción

Introducción: La recomendación actual para la estratificación de riesgo de las nuevas guías ACC/AHA sobre tratamiento del colesterolpara la reducción del riesgo cardiovascular aterosclerótico plantea un interrogante sobre la utilidad de la detección de aterosclerosissubclínica en prevención primaria.Objetivos: Analizar la prevalencia de aterosclerosis subclínica evaluada con eco carotídeo en los diferentes grupos de riesgo según lasnuevas guías. Analizar la prevalencia de aterosclerosis subclínicade los diferentes subgrupos cuando se agrega una subestratificaciónbasada en el número de factores de riesgo.Material y métodos: Se seleccionaron pacientes consecutivos de prevención primaria. Se excluyeron los pacientes con historia dediabetes y/o enfermedad coronaria y/o vascular periférica. Se definió aterosclerosis subclínicaa la presencia de una o más placasateroscleróticas detectadas por eco-Doppler carotídeo.Resultados: Se analizaron 541 pacientes, de los cuales 243 (45%) se estratificaron de riesgo bajo, 100 (18%) de riesgo intermedio y198 (37%) de riesgo alto. La prevalencia de placa (aterosclerosis subclínica) fue del 12% (IC 95% 9-17) en el grupo de riesgo bajo, del23% (IC 95% 16-32) en el de riesgo intermedio y del 41% (IC 95% 34-48) en el grupo de riesgo alto (p &lt; 0,001). Al analizar los diferentessubgrupos, en los pacientes de riesgo intermedio con dos o más factores de riesgo se observó una prevalencia de aterosclerosissubclínicadel 30% (IC 95% 20-43); en cambio, en el subgrupo con 0 a 1 factor de riesgo, la prevalencia fue del 14% (IC 95% 6-27) (p&lt; 0,05).Conclusiones: La evaluación de la aterosclerosis subclínica sumada al número de factores de riesgo permite identificar a sujetos condiferentes riesgos, más allá de la estratificación de las nuevas guías americanas, lo cual puede ser de utilidad al momento de decidirla terapéutica individual.

Background: The current recommendation for risk stratification of the new ACC/AHA guidelines on cholesterol therapy to reduceatherosclerotic cardiovascular risk questions the usefulness of subclinical atherosclerosis detection in primary prevention.Objectives: The aim of this study was to analyze the prevalence of subclinical atherosclerosis assessed by carotid echocardiographyin the different risk groups according to the new guidelines, and to evaluate the prevalence of subclinical atherosclerosis in the differentsubgroups when a sub-stratification based on the number of risk factors is added.Methods: Consecutive primary prevention patients were selected. Patients with a history of diabetes and/or coronary artery diseaseand/or peripheral vascular disease were excluded from the study. Subclinical atherosclerosis was defined as the presence of one ormore atherosclerotic plaques detected by carotid Doppler echocardiography.Results: Five hundred and forty one patients were analyzed; 243 (45%) were stratified as low risk, 100 (18%) as intermediate risk and198 (37%) as high risk. The prevalence of plaque (subclinical atherosclerosis) was 12% (95% CI 9-17) in the low risk group, 23% (95%CI 16-32) in the intermediate risk group and 41% (95% CI 34-48) in the high risk group (p&lt;0.001). When analyzing the differentsubgroups, the prevalence of subclinical atherosclerosis was 30% (95% CI 20-43) in the intermediate risk patients with two or morerisk factors; however, in the subgroup with 0 to 1 risk factors, the prevalence was 14% (95% CI 6-27) (p&lt;0.05).Conclusions: Subclinical atherosclerosis assessment added to the number of risk factors can identify subjects with different risksbeyond the stratification established by the new American guidelines, which can be useful when deciding individual therapeuticmanagement.

Metadatos destacados

Colecciones
Argentine Journal of Cardiology

Editor

Sociedad Argentina de Cardiología

Fuente

Revista Argentina de Cardiología; Vol 84, No 3 (2016); 215-221, Argentine Journal of Cardiology; Vol 84, No 3 (2016); 215-221

Citación

Bozzo, Raul Alberto; Instituto Cardiovascular de Buenos Aires (ICBA) et al., “VALOR DE LA ATEROSCLEROSIS SUBCLINICA EN LA DETERMINACIÓN DEL RIESGO CARDIOVASCULAR,” Archivo PPCT, consulta 2 de abril de 2026, http://archivoppct.caicyt.gov.ar/items/show/8681.

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Materia

Autor

Bozzo, Raul Alberto; Instituto Cardiovascular de Buenos Aires (ICBA)
Rey, Ricardo; ICBA
Manente, Diego; ICBA
Rostan, Maria; ICBA
Vitagliano, Laura; ICBA
Villamil, Alberto; ICBA

Fuente

Revista Argentina de Cardiología; Vol 84, No 3 (2016); 215-221
Argentine Journal of Cardiology; Vol 84, No 3 (2016); 215-221

Editor

Sociedad Argentina de Cardiología

Fecha

2016-06-28

Colaborador

sin financiación

Derechos

Los que firman al pié, certificamos que tenemos total responsabilidad por la conducción de este estudio y por el diseño y la interpretación de los datos. Nosotros escribimos el manuscrito y somos responsables por la decisión acerca del mismo. Cada uno de nosotros cumple la definición de autor como se afirma en el Comité Internacional de Editores de Revistas Médicas (International Committee of Medical Journal Editors, ver www.icmje.org). Nosotros hemos visto y aprobado el manuscrito final. Ni el artículo, ni ninguna parte esencial del mismo, incluido las tablas y las figuras, será publicado o admitido para arbitrar a otra parte antes de aparecer en la Revista.También notificamos haber leído la sección “conflicto de intereses”, y revelaríamos cualquiera que existiera. Dejamos constancia que si nuestro artículo se publicara en la RAC, cederíamos los derechos (copyright) a la Revista.Los documentos publicados en esta revista están bajo la licencia Creative Commons Atribución-NoComercial-Compartir-Igual 2.5 Argentina.
Those signing below certify that we have full responsibility for the conduction of this study and for the design and interpretation of the information. We wrote the manuscript and are responsible for its decision. Each of us fulfills the definition of authorship as stated by the International Committee of Medical Journal Editors ( www.icmje.org). We have signed and approved the final manuscript. Neither the manuscript, nor any essential part thereof, including tables and figures, will be published or accepted for refereeing elsewhere before being published in the Journal. We have also read the "Conflict of Interest" section and would disclose any existing. We state that if our manuscript is published in the RAC, we shall transfer the copyright to the Journal.

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eng
spa

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info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion