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COMPARACIÓN DE LA RESPUESTA ANTIHIPERTENSIVA AGUDA DE TELMISARTÁN E IRBESARTÁN EN RATAS ESPONTÁNEAMENTE HIPERTENSAS;
Comparison of the Acute Antihypertensive Response to Telmisartan and Irbesartan in Spontaneously Hypertensive Rats

Creators:Lucero, Martin; Cátedra de Farmacología,
Facultad de Farmacia y Bioquímica,
Universidad de Buenos Aires,, Santander, Yanina; Cátedra de Farmacología,
Facultad de Farmacia y Bioquímica,
Universidad de Buenos Aires,, Parola, Luciano; Cátedra de Farmacología,
Facultad de Farmacia y Bioquímica,
Universidad de Buenos Aires,, Del Mauro, Julieta Sofia; Cátedra de Farmacología,
Facultad de Farmacia y Bioquímica,
Universidad de Buenos Aires,, Moretón, Marcela; Departamento de Tecnología Farmacéutica, cInstituto de Fisiopatología y Bioquímica Clínica., Bertera, Facundo Martín, Chiappetta, Diego, Höcht, Christián; Cátedra de Farmacología,
Facultad de Farmacia y Bioquímica,
Universidad de Buenos Aires,, Taira, Carlos Alberto; Cátedra de Farmacología,
Facultad de Farmacia y Bioquímica,
Universidad de Buenos Aires,
2016-02-29

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Introducción: Telmisartan e irbesartan difieren en sus propiedades farmacológicas, incluyendo el tiempo de disociación desde el receptor AT1 y la capacidad de activar otros receptores. Objetivos: El presente trabajo comparó la respuesta cardiovascular aguda de la administración de una dosis única de irbesartan o telmisartan en ratas espontáneamente hipertensas (SHR). Materiales y Métodos: Se utilizaron 24 ratas SHR macho entre 250-275 g a las cuales se le canuló la arteria carótida y la vena femoral para la medición directa de la presión arterial media (PAM) y la administración de irbesartan 3-6 mg/kg o telmisartan 0,5-1 mg/kg. Se estimó el cambio en PAM,  frecuencia cardíaca y variabilidad de la presión arterial de corto plazo y latido-a-latido. Resultados: Aunque ambos antagonistas redujeron la PAM, telmisartan indujo una respuesta antihipertensiva más prolongada que irbesartan evidenciada por mayor reducción de la PAM luego de 180 minutos (-33,3±4,1% vs -16,3±4; p&lt;0.05). Telmisartan e irbesartán atenuaron de manera prolongada la variabilidad de la presión arterial de corto plazo sin diferencias entre ambos grupos experimentales. En el nivel de dosis más bajo, telmisartan disminuyó en mayor medida la frecuencia cardíaca y la variabilidad latido-a-latido en los diferentes dominios de frecuencia en comparación con irbesartán. Conclusiones: Telmisartan induce un efecto antihipertensivo más prolongado que irbesartan, probablemente como consecuencia de la disociación más lenta desde el receptor AT1. La mayor respuesta bradicardizante y la reducción superior de la variabilidad de la presión arterial latido-a-latido sugieren que telmisartan atenúa en mayor medida la actividad simpática en ratas SHR en comparación con irbesartan.

Introducción: El telmisartán y el irbesartán, dos de los principales antagonistas del receptor AT1 disponibles para el control de enfermedades cardiovasculares, difieren en sus propiedades farmacológicas, incluyendo el tiempo de disociación desde el receptor AT1 y la capacidad de activar otros receptores, con potencial impacto en su eficacia clínica relativa.Objetivo: Comparar la respuesta cardiovascular aguda de la administración de una dosis única de irbesartán o de telmisartán en ratas espontáneamente hipertensas.Material y métodos: Se utilizaron 24 ratas espontáneamente hipertensas macho de 250-275 g, a las que se les canuló la arteria carótida y la vena femoral para la medición directa de la presión arterial media (PAM) y la administración de irbesartán 3-6 mg/kg o de telmisartán 0,5-1 mg/kg. Se estimó el cambio en la PAM, la frecuencia cardíaca y la variabilidad de la presión arterial a corto plazo y latido-a-latido.Resultados: Aunque ambos antagonistas redujeron la PAM, el telmisartán indujo una respuesta antihipertensiva más prolongada que el irbesartán, evidenciada por mayor reducción de la PAM luego de 180 minutos (-33,3% ± 4,1% vs. -16,3% ± 4%; p &lt; 0,05). El telmisartán y el irbesartán atenuaron de manera prolongada la variabilidad de la presión arterial a corto plazo, sin diferencias entre ambos grupos experimentales. En el nivel de dosis más bajo, el telmisartán disminuyó en mayor medida la frecuencia cardíaca y la variabilidad latido-a-latido en los diferentes dominios de frecuencia en comparación con el irbesartán.Conclusiones: En ratas espontáneamente hipertensas, la administración de telmisartán induce un efecto antihipertensivo más prolongado y una respuesta bradicardizante mayor que el irbesartán. El análisis espectral de la variabilidad latido-a-latido sugiere que el telmisartán, en la dosis más baja, atenúa en mayor medida la actividad simpática vascular en comparación con el irbesartán.

Metadatos destacados

Colecciones
Argentine Journal of Cardiology

Editor

Sociedad Argentina de Cardiología

Fuente

Revista Argentina de Cardiología; Vol 84, No 1 (2016); 9-14, Argentine Journal of Cardiology; Vol 84, No 1 (2016); 9-14

Citación

Lucero, Martin; Cátedra de Farmacología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, et al., “COMPARACIÓN DE LA RESPUESTA ANTIHIPERTENSIVA AGUDA DE TELMISARTÁN E IRBESARTÁN EN RATAS ESPONTÁNEAMENTE HIPERTENSAS,” Archivo PPCT, consulta 2 de abril de 2026, http://archivoppct.caicyt.gov.ar/items/show/9022.

Dublin Core

Autor

Lucero, Martin; Cátedra de Farmacología,
Facultad de Farmacia y Bioquímica,
Universidad de Buenos Aires,
Santander, Yanina; Cátedra de Farmacología,
Facultad de Farmacia y Bioquímica,
Universidad de Buenos Aires,
Parola, Luciano; Cátedra de Farmacología,
Facultad de Farmacia y Bioquímica,
Universidad de Buenos Aires,
Del Mauro, Julieta Sofia; Cátedra de Farmacología,
Facultad de Farmacia y Bioquímica,
Universidad de Buenos Aires,
Moretón, Marcela; Departamento de Tecnología Farmacéutica, cInstituto de Fisiopatología y Bioquímica Clínica.
Bertera, Facundo Martín
Chiappetta, Diego
Höcht, Christián; Cátedra de Farmacología,
Facultad de Farmacia y Bioquímica,
Universidad de Buenos Aires,
Taira, Carlos Alberto; Cátedra de Farmacología,
Facultad de Farmacia y Bioquímica,
Universidad de Buenos Aires,

Fuente

Revista Argentina de Cardiología; Vol 84, No 1 (2016); 9-14
Argentine Journal of Cardiology; Vol 84, No 1 (2016); 9-14

Editor

Sociedad Argentina de Cardiología

Fecha

2016-02-29

Derechos

Los que firman al pié, certificamos que tenemos total responsabilidad por la conducción de este estudio y por el diseño y la interpretación de los datos. Nosotros escribimos el manuscrito y somos responsables por la decisión acerca del mismo. Cada uno de nosotros cumple la definición de autor como se afirma en el Comité Internacional de Editores de Revistas Médicas (International Committee of Medical Journal Editors, ver www.icmje.org). Nosotros hemos visto y aprobado el manuscrito final. Ni el artículo, ni ninguna parte esencial del mismo, incluido las tablas y las figuras, será publicado o admitido para arbitrar a otra parte antes de aparecer en la Revista.También notificamos haber leído la sección “conflicto de intereses”, y revelaríamos cualquiera que existiera. Dejamos constancia que si nuestro artículo se publicara en la RAC, cederíamos los derechos (copyright) a la Revista.Los documentos publicados en esta revista están bajo la licencia Creative Commons Atribución-NoComercial-Compartir-Igual 2.5 Argentina.
Those signing below certify that we have full responsibility for the conduction of this study and for the design and interpretation of the information. We wrote the manuscript and are responsible for its decision. Each of us fulfills the definition of authorship as stated by the International Committee of Medical Journal Editors ( www.icmje.org). We have signed and approved the final manuscript. Neither the manuscript, nor any essential part thereof, including tables and figures, will be published or accepted for refereeing elsewhere before being published in the Journal. We have also read the "Conflict of Interest" section and would disclose any existing. We state that if our manuscript is published in the RAC, we shall transfer the copyright to the Journal.

Formato

Idioma

eng
spa

Tipo

info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion