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<<777F940478098249972FADC5F065BF66>]>> startxref 116 %%EOF Sisyphus’s Dilemma: Measurement of Ventricular-Arterial Coupling by Doppler Echocardiography Predicts the Incidence of Right Ventricular Failure after Heart Transplantation Better than Right Catheterization - Archivo PPCT

Sisyphus’s Dilemma: Measurement of Ventricular-Arterial Coupling by Doppler Echocardiography Predicts the Incidence of Right Ventricular Failure after Heart Transplantation Better than Right Catheterization;
El dilema de Sísifo: la medición del acople ventrículo arterial medido por eco doppler predice la incidencia de falla de vd post trasplante cardíaco mejor que el cateterismo derecho

Creators:Bluro, Ignacio, Espinosa, Ezequiel, Marenchino, Ricardo Gustavo, Oberti, Pablo Fernando, Falconi, Mariano Luis, White, Patricio, Pizarro, Rodolfo, Belziti, César Antonio
2018-04-18

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Descripción

Background: Increased pulmonary vascular resistance, assessed by right catheterization, is usually mentioned as a relative contraindication for inclusion in the list of heart transplantation since it is associated with failure of the implanted right ventricle. There is evidence suggesting that the behavior of the pulmonary circulation depends on its interaction with theright ventricle, so a parameter that evaluates ventricular-arterial coupling could predict right ventricular failure better than isolated hemodynamic parameters. Objective: The aim of this study was to assess the ability of the tricuspid annular plane systolic excursion/pulmonary systolic pressure ratio (TAPSE/PSP) to predict the incidence of post-transplantation right ventricular failure compared with invasive hemodynamic parameters measured before transplantation. Methods: This was a retrospective cohort study using variables prospectively collected from the heart transplantation database of a University Hospital of the City of Buenos Aires. A total of 56 consecutive patients with complete echocardiographic and hemodynamic tests, undergoing heart transplantation between January 2012 and April 2017, were included in the study. Patients with more than one parenchymal transplantation, retransplantation, congenital heart disease, those requiring ventricular assistance at the time of pre-transplantation assessment or with incomplete data were excluded. Results: Three patients (5.3%) died within the first 30 days, 2 from right ventricular failure. No preoperative hemodynamic or echocardiographic parameters were associated with mortality. The incidence of right ventricular failure in the immediate postoperative period was 28.5% (16 patients). All the hemodynamic variables of pulmonary pressure and resistance, and the TAPSE/PSP ratio measured by echocardiography were associated with the development of right ventricular failure after heart transplantation. In a multivariate analysis including hemodynamic and echocardiographic variables, the TAPSE/PSP ratio was the only one independently associated with right ventricular failure (0R&gt;10, 95% CI 2.2-&gt;100, p=0.03). A TAPSE/PSP cut-off value of 0.26 showed sensitivity of 81% and specificity of 88% to predict right ventricular failure, with an area under the ROC curve of 0.84 ± 0.06 and X2=0 in the Hosmer-Lemeshow test (p=1) when considering quartiles of TAPSE/PSP. A predictive model of right ventricular failure composed of hemodynamic variables showed a sensitivity of 38% and a specificity of 97.5%, with an area under the ROC curve of 0.78±0.06 and X2=2.37 (p=0.3) in the Hosmer-Lemeshow test. Conclusions: We can conclude that the TAPSE/PSP ratio showed better discrimination and calibration to predict right ventricular failure, with 0.26 as the best prognostic performance value.

Introducción: El aumento de la resistencia vascular pulmonar, evaluada por cateterismo derecho suele citarse como una contraindicación relativa para la inclusión en lista de trasplante cardíaco, debido a que se asocia a la falla del ventrículo derecho  implantado. Existe evidencia que sugiere que el comportamiento de la circulación pulmonar depende de su interacción con el ventrículo derecho por lo que un parámetro que evalúe el acople ventrículo-arterial podría predecir la falla del ventrículo derecho mejor que parámetros hemodinámicos aislados. Objetivos: El objetivo de este estudio fue evaluar la capacidad de la relación TAPSE/PSP de predecir la incidencia de falla del ventrículo derecho postrasplante en relación con parámetros hemodinámicos invasivos medidos antes del trasplante. Material y Métodos: Estudio de cohorte retrospectiva en el que se utilizan variables recolectadas en forma prospectiva de la base de trasplante cardíaco de un Hospital Universitario de la Ciudad de Buenos Aires. Se incluyeron 56 pacientes consecutivos sometidos a trasplante cardíaco entre enero de 2012 y abril de 2017, de los cuales se contaba con la totalidad de las variables ecocardiográficas y hemodinámicas. Se excluyeron los pacientes con trasplante de más de un parénquima, los retrasplantes, aquellos con cardiopatías congénitas, los que presentaron requerimiento de asistencia ventricular al momento de la evaluación pretrasplante y los pacientes con datos incompletos. Resultados: Tres pacientes (5,3%) fallecieron dentro de los primeros 30 días, en 2 de estos se objetivó falla del ventrículo derecho. Ningún parámetro hemodinámico ni ecocardiográfico preoperatorio se asoció con mortalidad. La incidencia de falla del ventrículo derecho en el posoperatorio inmediato fue del 28,5% (16 pacientes). Todas las variables hemodinámicas de presión y resistencia pulmonar, y la relación TAPSE/PSP medida por ecocardiografía se asociaron con el desarrollo de falla del ventrículo derecho postrasplante. Luego de realizar un análisis multivariado que incluyó variables hemodinámicas y ecocardiográficas, la relación TAPSE/PSP fue la única que se asoció en forma independiente con falla del ventrículo derecho (OR &gt; 10; IC95 2,2-&gt; 100; p = 0,03). Un valor de corte de TAPSE/PSP de 0,26 mostró una sensibilidad de 81% y una especificidad de 88% para predecir la falla del ventrículo derecho, con un ABC ROC de 0,84 ± 0,06 y el valor de X2 en la prueba de Hosmer-Lemeshow fue 0 (p = 1) al considerar cuartiles de TAPSE/PSP. Un modelo predictivo de falla de ventrículo derecho compuesto por variables hemodinámicas mostró una sensibilidad del 38% y una especificidad del 97,5%, con un área bajo la curva ROC de 0,78 ± 0,06 y un valor de X2 en la prueba de Hosmer-Lemeshow de 2,37 (p = 0,3). Conclusiones: Podemos concluir que la relación TAPSE/PSP mostró una mejor discriminación y calibración para predecir la falla del ventrículo derecho, y 0,26 fue el valor con mejor desempeño pronóstico.

Metadatos destacados

Colecciones
Argentine Journal of Cardiology

Editor

Sociedad Argentina de Cardiología

Fuente

Revista Argentina de Cardiología; Vol 85, No 6 (2017); 527-533, Argentine Journal of Cardiology; Vol 85, No 6 (2017); 527-533

Citación

Bluro, Ignacio et al., “Sisyphus’s Dilemma: Measurement of Ventricular-Arterial Coupling by Doppler Echocardiography Predicts the Incidence of Right Ventricular Failure after Heart Transplantation Better than Right Catheterization,” Archivo PPCT, consulta 4 de abril de 2026, http://archivoppct.caicyt.gov.ar/items/show/9426.

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Autor

Bluro, Ignacio
Espinosa, Ezequiel
Marenchino, Ricardo Gustavo
Oberti, Pablo Fernando
Falconi, Mariano Luis
White, Patricio
Pizarro, Rodolfo
Belziti, César Antonio

Fuente

Revista Argentina de Cardiología; Vol 85, No 6 (2017); 527-533
Argentine Journal of Cardiology; Vol 85, No 6 (2017); 527-533

Editor

Sociedad Argentina de Cardiología

Fecha

2018-04-18

Derechos

Los que firman al pié, certificamos que tenemos total responsabilidad por la conducción de este estudio y por el diseño y la interpretación de los datos. Nosotros escribimos el manuscrito y somos responsables por la decisión acerca del mismo. Cada uno de nosotros cumple la definición de autor como se afirma en el Comité Internacional de Editores de Revistas Médicas (International Committee of Medical Journal Editors, ver www.icmje.org). Nosotros hemos visto y aprobado el manuscrito final. Ni el artículo, ni ninguna parte esencial del mismo, incluido las tablas y las figuras, será publicado o admitido para arbitrar a otra parte antes de aparecer en la Revista.También notificamos haber leído la sección “conflicto de intereses”, y revelaríamos cualquiera que existiera. Dejamos constancia que si nuestro artículo se publicara en la RAC, cederíamos los derechos (copyright) a la Revista.Los documentos publicados en esta revista están bajo la licencia Creative Commons Atribución-NoComercial-Compartir-Igual 2.5 Argentina.
Those signing below certify that we have full responsibility for the conduction of this study and for the design and interpretation of the information. We wrote the manuscript and are responsible for its decision. Each of us fulfills the definition of authorship as stated by the International Committee of Medical Journal Editors ( www.icmje.org). We have signed and approved the final manuscript. Neither the manuscript, nor any essential part thereof, including tables and figures, will be published or accepted for refereeing elsewhere before being published in the Journal. We have also read the "Conflict of Interest" section and would disclose any existing. We state that if our manuscript is published in the RAC, we shall transfer the copyright to the Journal.

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